Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
12 11 2019
12 11 2019
Historique:
received:
25
07
2019
accepted:
22
10
2019
entrez:
14
11
2019
pubmed:
14
11
2019
medline:
11
11
2020
Statut:
epublish
Résumé
Upon intravenous injection of tumour necrosis factor (TNF) in mice, a systemic inflammatory response syndrome (SIRS) is initiated, characterized by an acute cytokine storm and induction of vascular hyperpermeability. Connexin43 hemichannels have been implicated in various pathological conditions, e.g. ischemia and inflammation, and can lead to detrimental cellular outcomes. Here, we explored whether targeting connexin43 hemichannels could alleviate TNF-induced endothelial barrier dysfunction and lethality in SIRS. Therefore, we verified whether administration of connexin43-targeting-peptides affected survival, body temperature and vascular permeability in vivo. In vitro, TNF-effects on connexin43 hemichannel function were investigated by single-channel studies and Ca
Identifiants
pubmed: 31719598
doi: 10.1038/s41598-019-52900-4
pii: 10.1038/s41598-019-52900-4
pmc: PMC6851386
doi:
Substances chimiques
Chemokines
0
Connexin 43
0
Cytokines
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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