Effects of a multispecies synbiotic on intestinal mucosa immune responses.
Bifidobacterium
Immune response
Lactobacillus
Streptococcus
Synbiotic
Journal
Iranian journal of microbiology
ISSN: 2008-3289
Titre abrégé: Iran J Microbiol
Pays: Iran
ID NLM: 101518404
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
entrez:
14
11
2019
pubmed:
14
11
2019
medline:
14
11
2019
Statut:
ppublish
Résumé
Probiotics and prebiotics are known to regulate immune responses. A synbiotic is a product that combines probiotics and prebiotics in a single dosage form. In this study, we attempt to present the effects of a multispecies synbiotic on intestinal mucosa immune responses after exposure to Totally 21 male Balb/c mice were randomly classified into two groups. The K-I group received LPS and a synbiotic, and the K-II group received LPS alone. The synbiotic was administered for 21 consecutive days, whereas LPS was administered once on the 15 An independent-samples t-test revealed significant increases of the numbers of IgA- (p = 0.027) and CD4-expressing cells (p = 0.009) but not the number of CD8-expressing cells in the K-I group compared with those in the K-II group. The multispecies synbiotic had immunoregulatory effects on IgA and CD4 expression in LPS-exposed mice.
Sections du résumé
BACKGROUND AND OBJECTIVES
OBJECTIVE
Probiotics and prebiotics are known to regulate immune responses. A synbiotic is a product that combines probiotics and prebiotics in a single dosage form. In this study, we attempt to present the effects of a multispecies synbiotic on intestinal mucosa immune responses after exposure to
MATERIALS AND METHODS
METHODS
Totally 21 male Balb/c mice were randomly classified into two groups. The K-I group received LPS and a synbiotic, and the K-II group received LPS alone. The synbiotic was administered for 21 consecutive days, whereas LPS was administered once on the 15
RESULTS
RESULTS
An independent-samples t-test revealed significant increases of the numbers of IgA- (p = 0.027) and CD4-expressing cells (p = 0.009) but not the number of CD8-expressing cells in the K-I group compared with those in the K-II group.
CONCLUSION
CONCLUSIONS
The multispecies synbiotic had immunoregulatory effects on IgA and CD4 expression in LPS-exposed mice.
Types de publication
Journal Article
Langues
eng
Pagination
300-304Informations de copyright
Copyright© 2019 Iranian Neuroscience Society.
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