Time to diagnosis of tuberculosis is greater in older patients: a retrospective cohort review.
Journal
ERJ open research
ISSN: 2312-0541
Titre abrégé: ERJ Open Res
Pays: England
ID NLM: 101671641
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
29
11
2018
accepted:
29
07
2019
entrez:
14
11
2019
pubmed:
14
11
2019
medline:
14
11
2019
Statut:
epublish
Résumé
Age-related immunosenescence influences the presentation of tuberculosis (TB) in older patients. Here, we explore the clinical and radiological presentation of TB in the elderly and the factors associated with time to treatment for TB. This is a retrospective cohort study comparing the clinical, radiological and demographic characteristics of TB patients aged ≥65 years with TB patients aged 18-64 years in a large cohort of TB patients in the UK. Factors associated with the time to presentation and time to treatment were identified using a multivariable analysis model. 1023 patients were included in the analyses: 679 patients aged 18-64 years and 344 patients aged ≥65 years. "Classical" symptoms of TB (cough, haemoptysis, fever, nights sweats and weight loss) were less common among older patients with pulmonary TB (PTB) (p<0.05), but dyspnoea was more common among older patients (p=0.001). Time from presenting in secondary care to starting treatment was shorter in younger compared with older patients: 3 Older patients aged ≥65 years with TB had fewer "classical" clinical and radiological presentations of TB, which may explain longer times to starting treatment from symptom onset compared with younger patients aged <65 years.
Identifiants
pubmed: 31720296
doi: 10.1183/23120541.00228-2018
pii: 00228-2018
pmc: PMC6826249
pii:
doi:
Types de publication
Journal Article
Langues
eng
Informations de copyright
Copyright ©ERS 2019.
Déclaration de conflit d'intérêts
Conflict of interest: A. Abbara has nothing to disclose. Conflict of interest: S.M. Collin has nothing to disclose. Conflict of interest: O.M. Kon has nothing to disclose. Conflict of interest: K. Buell has nothing to disclose. Conflict of interest: A. Sullivan has nothing to disclose. Conflict of interest: J. Barrett has nothing to disclose. Conflict of interest: T. Corrah has nothing to disclose. Conflict of interest: A. McGregor has nothing to disclose. Conflict of interest: T. Hansel has nothing to disclose. Conflict of interest: L. John has nothing to disclose. Conflict of interest: R.N. Davidson has nothing to disclose.
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