Established and emerging therapeutic uses of PDE type 5 inhibitors in cardiovascular disease.
Journal
British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
22
07
2019
revised:
15
10
2019
accepted:
21
10
2019
pubmed:
14
11
2019
medline:
22
6
2021
entrez:
14
11
2019
Statut:
ppublish
Résumé
PDE type 5 inhibitors (PDE5Is), such as sildenafil, tadalafil and vardenafil, are a class of drugs used to prolong the physiological effects of NO/cGMP signalling in tissues through the inhibition of cGMP degradation. Although these agents were originally developed for the treatment of hypertension and angina, unanticipated side effects led to advances in the treatment of erectile dysfunction and, later, pulmonary arterial hypertension. In the last decade, accumulating evidence suggests that PDE5Is may confer a wider range of clinical benefits than was previously recognised. This has led to a broader interest in the cardiovascular therapeutic potential of PDE5Is, in conditions such as hypertension, myocardial infarction, stroke, peripheral arterial disease, chronic kidney disease and diabetes mellitus. Here, we review the pharmacological properties and established licensed uses of this class of drug, along with emerging therapeutic developments and possible future indications.
Identifiants
pubmed: 31721165
doi: 10.1111/bph.14920
pmc: PMC7707100
doi:
Substances chimiques
Phosphodiesterase 5 Inhibitors
0
Tadalafil
742SXX0ICT
Sildenafil Citrate
BW9B0ZE037
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
5467-5488Subventions
Organisme : MRC Clinical Research Training Fellowship
ID : MR/R017840/1
Organisme : BHF Intermediate Clinical Research Fellowship
ID : FS/13/30/29994
Organisme : British Heart Foundation (BHF) Centre of Research Excellence Award
ID : RE/08/001/23904
Informations de copyright
© 2019 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.
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