Accelerating the Search for Interventions Aimed at Expanding the Health Span in Humans: The Role of Epidemiology.

Aging / physiology Animals Health Status Humans Longevity / physiology Models, Animal Research Design
Epidemiology Longevity Successful aging

Journal

The journals of gerontology. Series A, Biological sciences and medical sciences
ISSN: 1758-535X
Titre abrégé: J Gerontol A Biol Sci Med Sci
Pays: United States
ID NLM: 9502837

Informations de publication

Date de publication:
01 01 2020
Historique:
received: 17 09 2019
pubmed: 14 11 2019
medline: 13 8 2020
entrez: 14 11 2019
Statut: ppublish

Résumé

Extensive work in basic and clinical science suggests that biological mechanisms of aging are causally related to the development of disease and disability in late life. Modulation of the biological mechanisms of aging can extend both life span and health span in animal models, but translation to humans has been slow. Summary of workshop proceedings from the 2018-2019 Epidemiology of Aging Workshop hosted by the Intramural Research Program at the National Institute on Aging. Epidemiologic studies play a vital role to progress in this field, particularly in evaluating new risk factors and measures of biologic aging that may influence health span, as well as developing relevant outcome measures that are robust and relevant for older individuals. Appropriately designed epidemiological studies are needed to identify targets for intervention and to inform study design and sample size estimates for future clinical trials designed to promote health span.

Sections du résumé

BACKGROUND
Extensive work in basic and clinical science suggests that biological mechanisms of aging are causally related to the development of disease and disability in late life. Modulation of the biological mechanisms of aging can extend both life span and health span in animal models, but translation to humans has been slow.
METHODS
Summary of workshop proceedings from the 2018-2019 Epidemiology of Aging Workshop hosted by the Intramural Research Program at the National Institute on Aging.
RESULTS
Epidemiologic studies play a vital role to progress in this field, particularly in evaluating new risk factors and measures of biologic aging that may influence health span, as well as developing relevant outcome measures that are robust and relevant for older individuals.
CONCLUSIONS
Appropriately designed epidemiological studies are needed to identify targets for intervention and to inform study design and sample size estimates for future clinical trials designed to promote health span.

Identifiants

DOI: 10.1093/gerona/glz230 PMID: 31722007 PMC: PMC7175971
pubmed: 31722007
pii: 5622775
doi: 10.1093/gerona/glz230
pmc: PMC7175971
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

77-86

Subventions

Organisme : NIA NIH HHS
ID : P30 AG049638
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES025225
Pays : United States
Organisme : NIA NIH HHS
ID : UH2 AG056933
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI142086
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057136
Pays : United States
Organisme : NIA NIH HHS
ID : UH2 AG056925
Pays : United States
Organisme : Medical Research Council
ID : MR/M023095/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : U24 AG051129
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG060018
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG052964
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG062682
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM124922
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG059416
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL130114
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG059729
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG023744
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG023755
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG053198
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG024827
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG057545
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG021332
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057002
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG048023
Pays : United States
Organisme : NIA NIH HHS
ID : UH3 AG056933
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG052608
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES009089
Pays : United States

Informations de copyright

© The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Auteurs

Anne B Newman (AB)

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania.
Department of Geriatric Medicine, School of Medicine, University of Pittsburgh, Pennsylvania.

Stephen B Kritchevsky (SB)

Sticht Center for Health Aging and Alzheimer's Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Jack M Guralnik (JM)

Department of Epidemiology and Public Health, School of Medicine, University of Maryland, Baltimore, Maryland.

Steven R Cummings (SR)

San Francisco Coordinating Center, California Pacific Medical Center Research Institute San Fransisco, California, Bethesda, Maryland.

Marcel Salive (M)

National Institute on Aging, National Institutes of Health, Bethesda, Maryland.

George A Kuchel (GA)

University of Connecticut Center on Aging, University of Connecticut Health, Farmington, CT, Baltimore, Maryland.

Jennifer Schrack (J)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Martha Clare Morris (MC)

Department of Internal Medicine, Rush Medical College, Rush University, Chicago, Illinois.

David Weir (D)

Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, Michigan, New York, New York.

Andrea Baccarelli (A)

Department of Environmental Health Sciences, Laboratory of Precision Environmental Biosciences, Columbia University Mailman School of Public Health, New York, New York.

Joanne M Murabito (JM)

Department of Medicine, Section of General Internal Medicine, Boston University School of Medicine, Boston, Massachusetts.

Yoav Ben-Shlomo (Y)

Population Health Sciences, University of Bristol, Bristol, UK.
National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care West (NIHR CLAHRC West), University Hospitals Bristol NHS Foundation Trust, Bristol, UK.

Mark A Espeland (MA)

Department of Biostatistics and Data Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina.

James Kirkland (J)

Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota.

David Melzer (D)

College of Medicine and Health, University of Exeter, Exeter, UK.
Center on Aging, School of Medicine, University of Connecticut, Farmington, Connecticut.

Luigi Ferrucci (L)

Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Accelerating the Search for Interventions...
questionsmedicales.fr › Eucaryotes › Animaux › Accelerating the Search for Interventions...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Accelerating the Search for Interventions...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Accelerating the Search for Interventions...
questionsmedicales.fr › Phénomènes physiologiques › Longévité › Accelerating the Search for Interventions...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Accelerating the Search for Interventions...
questionsmedicales.fr › Disciplines des sciences naturelles › Science › Recherche › Plan de recherche › Accelerating the Search for Interventions...