The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches.

Animals Axons / metabolism COS Cells Chlorocebus aethiops Female Humans Male Membrane Proteins / genetics Mice PTEN Phosphohydrolase / genetics Phosphatidylinositol 3-Kinases / genetics Phosphatidylinositol Phosphates / genetics
PI3K signaling PTEN axon morphogenesis branching neuronal growth homeostasis phosphoinositide signaling plasticity-related gene family

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
12 11 2019
Historique:
received: 08 10 2018
revised: 09 08 2019
accepted: 09 10 2019
entrez: 14 11 2019
pubmed: 14 11 2019
medline: 17 9 2020
Statut: ppublish

Résumé

In developing neurons, phosphoinositide 3-kinases (PI3Ks) control axon growth and branching by positively regulating PI3K/PI(3,4,5)P

Identifiants

DOI: 10.1016/j.celrep.2019.10.039 PMID: 31722215 PMC: PMC6856728
pubmed: 31722215
pii: S2211-1247(19)31353-1
doi: 10.1016/j.celrep.2019.10.039
pmc: PMC6856728
pii:
doi:

Substances chimiques

Membrane Proteins 0
Phosphatidylinositol Phosphates 0
phosphatidylinositol 3,4,5-triphosphate 0
PTEN Phosphohydrolase EC 3.1.3.67
Pten protein, mouse EC 3.1.3.67

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2028-2040.e8

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.

Auteurs

Annika Brosig (A)

Institute of Biochemistry, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Joachim Fuchs (J)

Institute of Biochemistry, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Fatih Ipek (F)

Institute of Biochemistry, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Group Protein X-ray Crystallography and Signal Transduction, Institute of Medical Physics and Biophysics, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Cristina Kroon (C)

Institute of Biochemistry, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Sandra Schrötter (S)

Institute of Biochemistry, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Department of Genetics and Complex Diseases, T.H. Chan Harvard School of Public Health, Boston, MA 02120, USA.

Mayur Vadhvani (M)

Institute of Biochemistry, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Alexandra Polyzou (A)

Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.

Julia Ledderose (J)

Institute of Biochemistry, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Michiel van Diepen (M)

Institute of Infectious Disease and Molecular Medicine, Faculty of Health Science, University of Cape Town, Cape Town, South Africa.

Hermann-Georg Holzhütter (HG)

Institute of Biochemistry, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Thorsten Trimbuch (T)

Institute of Neurophysiology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Niclas Gimber (N)

Advanced Medical Bioimaging Core Facility (AMBIO), Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Jan Schmoranzer (J)

Advanced Medical Bioimaging Core Facility (AMBIO), Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Ivo Lieberam (I)

Centre for Stem Cells and Regenerative Medicine and Centre for Developmental Neurobiology, MRC Centre for Neurodevelopmental Disorders, King's College, London, UK.

Christian Rosenmund (C)

NeuroCure-Cluster of Excellence, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Institute of Neurophysiology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Christian Spahn (C)

NeuroCure-Cluster of Excellence, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Institute of Medical Physics and Biophysics, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Patrick Scheerer (P)

Group Protein X-ray Crystallography and Signal Transduction, Institute of Medical Physics and Biophysics, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Michal Szczepek (M)

Group Protein X-ray Crystallography and Signal Transduction, Institute of Medical Physics and Biophysics, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

George Leondaritis (G)

Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece. Electronic address: gleondar@uoi.gr.

Britta J Eickholt (BJ)

Institute of Biochemistry, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; NeuroCure-Cluster of Excellence, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany. Electronic address: britta.eickholt@charite.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The Axonal Membrane Protein PRG2 Inhibits PTEN...
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Axones › The Axonal Membrane Protein PRG2 Inhibits PTEN...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Cellules COS › The Axonal Membrane Protein PRG2 Inhibits PTEN...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Cercopithecus › Cercopithecus aethiops › The Axonal Membrane Protein PRG2 Inhibits PTEN...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Axonal Membrane Protein PRG2 Inhibits PTEN...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › The Axonal Membrane Protein PRG2 Inhibits PTEN...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The Axonal Membrane Protein PRG2 Inhibits PTEN...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines suppresseurs de tumeurs › Phosphohydrolase PTEN › The Axonal Membrane Protein PRG2 Inhibits PTEN...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphatidylinositol 3-kinases › The Axonal Membrane Protein PRG2 Inhibits PTEN...
questionsmedicales.fr › Lipides › Lipides membranaires › Phospholipides › Glycérophosphate › Acides phosphatidiques › Glycérophospholipides › Phosphatidyl inositols › Phosphates phosphatidylinositol › The Axonal Membrane Protein PRG2 Inhibits PTEN...