Altered brain connectivity in sudden unexpected death in epilepsy (SUDEP) revealed using resting-state fMRI.
Amygdala
Graph theory
Rs-fmri
SUDEP
Thalamus
Journal
NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070
Informations de publication
Date de publication:
2019
2019
Historique:
received:
04
07
2019
revised:
22
10
2019
accepted:
24
10
2019
pubmed:
14
11
2019
medline:
23
9
2020
entrez:
14
11
2019
Statut:
ppublish
Résumé
The circumstances surrounding SUDEP suggest autonomic or respiratory collapse, implying central failure of regulation or recovery. Characterisation of the communication among brain areas mediating such processes may shed light on mechanisms and noninvasively indicate risk. We used rs-fMRI to examine network properties among brain structures in people with epilepsy who suffered SUDEP (n = 8) over an 8-year follow-up period, compared with matched high- and low-risk subjects (n = 16/group) who did not suffer SUDEP during that period, and a group of healthy controls (n = 16). Network analysis was employed to explore connectivity within a 'regulatory-subnetwork' of brain regions involved in autonomic and respiratory regulation, and over the whole-brain. Modularity, the extent of network organization into separate modules, was significantly reduced in the regulatory-subnetwork, and the whole-brain, in SUDEP and high-risk. Increased participation, a local measure of inter-modular belonging, was evident in SUDEP and high-risk groups, particularly among thalamic structures. The medial prefrontal thalamus was increased in SUDEP compared with all other control groups, including high-risk. Patterns of hub topology were similar in SUDEP and high-risk, but were more extensive in low-risk patients, who displayed greater hub prevalence and a radical reorganization of hubs in the subnetwork. SUDEP is associated with reduced functional organization among cortical and sub-cortical brain regions mediating autonomic and respiratory regulation. Living high-risk subjects demonstrated similar patterns, suggesting such network measures may provide prospective risk-indicating value, though a crucial difference between SUDEP and high-risk was altered connectivity of the medial thalamus in SUDEP, which was also elevated compared with all sub-groups. Disturbed thalamic connectivity may reflect a potential non-invasive marker of elevated SUDEP risk.
Identifiants
pubmed: 31722289
pii: S2213-1582(19)30407-3
doi: 10.1016/j.nicl.2019.102060
pmc: PMC6849487
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102060Subventions
Organisme : NINDS NIH HHS
ID : U01 NS090407
Pays : United States
Organisme : Medical Research Council
ID : G0301067
Pays : United Kingdom
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
Références
Int J Cardiol. 2010 May 28;141(2):122-31
pubmed: 19910061
J Comp Neurol. 1998 Nov 30;401(4):480-505
pubmed: 9826274
Epilepsia. 2012 Feb;53(2):272-82
pubmed: 22221253
Sci Rep. 2017 Dec 4;7(1):16868
pubmed: 29203874
Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20608-13
pubmed: 23185007
Front Syst Neurosci. 2010 Oct 08;4:147
pubmed: 21031030
Brain. 2015 Oct;138(Pt 10):2907-19
pubmed: 26264515
Front Neurol. 2017 Oct 16;8:544
pubmed: 29085330
Hum Brain Mapp. 2017 Aug;38(8):4125-4156
pubmed: 28544076
Hum Brain Mapp. 2018 Dec;39(12):4820-4830
pubmed: 30096213
Neuroimage Clin. 2018 Jul 18;20:205-215
pubmed: 30094170
Neurology. 2017 Feb 14;88(7):701-705
pubmed: 28087822
Neuroimage. 2002 Apr;15(4):870-8
pubmed: 11906227
Epilepsy Behav. 2011 Oct;22(2):401-3
pubmed: 21816679
PLoS Biol. 2008 Jul 1;6(7):e159
pubmed: 18597554
Epilepsy Behav. 2014 Dec;41:33-8
pubmed: 25277976
Brain Res. 1985 Aug 5;340(1):71-7
pubmed: 4027647
Ann Neurol. 2018 Mar;83(3):460-471
pubmed: 29420859
Neuroimage Clin. 2016 Feb 18;11:302-315
pubmed: 26977400
Neural Netw. 2015 Feb;62:3-10
pubmed: 25124068
Front Neurol. 2019 Mar 05;10:185
pubmed: 30891003
Front Hum Neurosci. 2013 Oct 04;7:623
pubmed: 24109446
J Neurosci. 2015 Jul 15;35(28):10281-9
pubmed: 26180203
Lancet Neurol. 2013 Oct;12(10):966-77
pubmed: 24012372
Neuron. 2013 Aug 21;79(4):798-813
pubmed: 23972601
Front Physiol. 2015 Sep 01;6:240
pubmed: 26388780
Front Neurol. 2017 Sep 21;8:473
pubmed: 28983274
Neurology. 2013 Jul 9;81(2):134-43
pubmed: 23719145
Epilepsia. 2012 Feb;53(2):227-33
pubmed: 22191982
Neuroimage. 2010 Sep;52(3):1059-69
pubmed: 19819337
Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13773-8
pubmed: 16174729
Epilepsia. 2012 Feb;53(2):253-7
pubmed: 22192074
Epilepsia. 2012 Feb;53(2):249-52
pubmed: 22191685
J Neurosci. 2006 Jan 4;26(1):63-72
pubmed: 16399673
Epilepsia. 2018 Mar;59(3):573-582
pubmed: 29336036
Front Neurosci. 2016 Jan 26;9:513
pubmed: 26858595
PLoS One. 2016 Dec 22;11(12):e0169015
pubmed: 28006029
Electroencephalogr Clin Neurophysiol. 1989 Jun;72(6):463-70
pubmed: 2471614
Nat Rev Neurol. 2014 May;10(5):271-82
pubmed: 24752120
Curr Opin Neurol. 2012 Apr;25(2):201-7
pubmed: 22274774
Prog Brain Res. 1991;87:253-68
pubmed: 1866449
JAMA Neurol. 2018 Feb 1;75(2):194-202
pubmed: 29181526
Cereb Cortex. 2016 Aug;26(8):3508-26
pubmed: 27230218
Sci Transl Med. 2015 Apr 8;7(282):282ra46
pubmed: 25855492
Neuroimage Clin. 2014 Jul 09;5:208-16
pubmed: 25068110
J Neurol Neurosurg Psychiatry. 2016 Jun;87(6):642-9
pubmed: 26216941