Despite early antiretroviral therapy effector memory and follicular helper CD4 T cells are major reservoirs in visceral lymphoid tissues of SIV-infected macaques.
Animals
Anti-Retroviral Agents
CD4-Positive T-Lymphocytes
/ physiology
DNA, Viral
/ genetics
Disease Reservoirs
Germinal Center
/ immunology
HIV Infections
/ immunology
HIV-1
/ physiology
Humans
Immunologic Memory
Lymphoid Tissue
/ physiology
Macaca
RNA, Small Nuclear
/ genetics
Simian Acquired Immunodeficiency Syndrome
/ immunology
Simian Immunodeficiency Virus
/ physiology
Spleen
/ physiology
T-Lymphocytes, Cytotoxic
/ immunology
Viral Load
Virus Replication
Viscera
/ immunology
Journal
Mucosal immunology
ISSN: 1935-3456
Titre abrégé: Mucosal Immunol
Pays: United States
ID NLM: 101299742
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
31
07
2019
accepted:
22
10
2019
pubmed:
15
11
2019
medline:
8
1
2021
entrez:
15
11
2019
Statut:
ppublish
Résumé
Whereas antiretroviral therapy (ART) suppresses viral replication, ART discontinuation results in viral rebound, indicating the presence of viral reservoirs (VRs) established within lymphoid tissues. Herein, by sorting CD4 T-cell subsets from the spleen, mesenteric and peripheral lymph nodes (LNs) of SIVmac251-infected rhesus macaques (RMs), we demonstrate that effector memory (TEM) and follicular helper (TFH) CD4
Identifiants
pubmed: 31723251
doi: 10.1038/s41385-019-0221-x
pii: S1933-0219(22)00249-5
pmc: PMC6914669
mid: NIHMS1541582
doi:
Substances chimiques
Anti-Retroviral Agents
0
DNA, Viral
0
RNA, Small Nuclear
0
U5 small nuclear RNA
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
149-160Subventions
Organisme : NIAID NIH HHS
ID : R21 AI116200
Pays : United States
Organisme : CIHR
ID : HBF-123682
Pays : Canada
Organisme : CIHR
ID : HBF-126786
Pays : Canada
Organisme : CIHR
ID : MOP-133476
Pays : Canada
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