Use of nebulized naloxone to reverse methadone overdose - A case report and review of literature.
Naloxone
nebulized naloxone
opioid overdose
Journal
Journal of community hospital internal medicine perspectives
ISSN: 2000-9666
Titre abrégé: J Community Hosp Intern Med Perspect
Pays: United States
ID NLM: 101601396
Informations de publication
Date de publication:
2019
2019
Historique:
received:
17
03
2019
accepted:
20
08
2019
entrez:
15
11
2019
pubmed:
15
11
2019
medline:
15
11
2019
Statut:
epublish
Résumé
Opioid use is a frequent cause of morbidity and mortality in the USA. We report a case of methadone overdose reversed with naloxone nebulization. Peripheral IV access can be difficult to obtain in patients with a history of IV drug abuse making needless routes of naloxone administration useful. When naloxone is administered as a bolus, chronically opioid dependent patients are more prone to violent withdrawal symptoms. When successful, nebulized naloxone reverses intoxication and allows the patient to self-titrate the discontinuation of naloxone when they are alert enough to remove the mask. Nebulized naloxone can provide needleless and noninvasive administration for the reversal of opioid overdose.
Identifiants
pubmed: 31723388
doi: 10.1080/20009666.2019.1659664
pii: 1659664
pmc: PMC6830244
doi:
Types de publication
Case Reports
Langues
eng
Pagination
422-424Informations de copyright
© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of Greater Baltimore Medical Center.
Références
Ann Pharmacother. 2018 May;52(5):495-496
pubmed: 29319329
Ind Health. 2009 Apr;47(2):139-44
pubmed: 19367042
J Emerg Med. 2003 Feb;24(2):185-7
pubmed: 12609650
Acad Emerg Med. 1998 Apr;5(4):283-5
pubmed: 9562188
Am J Emerg Med. 2013 Mar;31(3):585-8
pubmed: 23347721
Ann Pharmacother. 1992 Feb;26(2):196-8
pubmed: 1554930
Prehosp Emerg Care. 2012 Apr-Jun;16(2):289-92
pubmed: 22191727
Ther Drug Monit. 2008 Aug;30(4):490-6
pubmed: 18641540
Acad Emerg Med. 1998 Apr;5(4):293-9
pubmed: 9562190
Eur J Pharmacol. 1982 Feb 19;78(1):61-70
pubmed: 6281030
J Opioid Manag. 2017 Jul/Aug;13(4):253-260
pubmed: 28953317
Ann Emerg Med. 1983 Jul;12(7):438-45
pubmed: 6309038