Cardiac and hepatic siderosis in myelodysplastic syndrome, thalassemia and diverse causes of transfusion-dependent anemia: the TIMES study.
Journal
HemaSphere
ISSN: 2572-9241
Titre abrégé: Hemasphere
Pays: United States
ID NLM: 101740619
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
01
10
2018
revised:
30
01
2019
accepted:
20
03
2019
entrez:
15
11
2019
pubmed:
15
11
2019
medline:
15
11
2019
Statut:
epublish
Résumé
The significant morbidity and mortality associated with iron overload can be reduced by effective iron chelation. Magnetic resonance imaging (MRI) provides accurate and reproducible iron load assessment. The aim of this epidemiological study was to assess the prevalence and severity of cardiac and hepatic siderosis by MRI and to evaluate the impact of MRI on clinical management in patients with transfusion-dependent anemia and non-transfusion-dependent thalassemia (NTDT). We enrolled 243 patients with myelodysplastic syndromes (MDS), thalassemia major (TM), NTDT or other chronic anemia. Overall, 10% and 48% had cardiac and hepatic siderosis, respectively. Mean liver iron concentration (LIC) was above target range in all groups; mean myocardial T2
Identifiants
pubmed: 31723837
doi: 10.1097/HS9.0000000000000224
pii: HemaSphere-2018-0178
pmc: PMC6746020
doi:
Banques de données
ClinicalTrials.gov
['NCT01736540']
Types de publication
Journal Article
Langues
eng
Pagination
e224Informations de copyright
Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Hematology Association.
Références
Blood. 2006 May 1;107(9):3738-44
pubmed: 16352815
Int J Hematol. 2011 Nov;94(5):453-60
pubmed: 21993873
Intern Med J. 2011 Jul;41(7):516-24
pubmed: 21615659
Eur J Haematol. 2007 Jun;78(6):540-2
pubmed: 17391307
Cold Spring Harb Perspect Med. 2012 Dec 01;2(12):a011726
pubmed: 23209183
Ther Clin Risk Manag. 2007 Jun;3(2):291-9
pubmed: 18360637
Am J Hematol. 2011 May;86(5):433-6
pubmed: 21523808
PLoS One. 2017 Mar 3;12(3):e0172147
pubmed: 28257476
Cancer Res. 2007 Sep 15;67(18):8762-71
pubmed: 17875717
Expert Rev Hematol. 2011 Jun;4(3):353-66
pubmed: 21668399
J Magn Reson Imaging. 2011 Jul;34(1):56-9
pubmed: 21608067
Schizophr Res. 2008 Mar;100(1-3):53-9
pubmed: 18083007
Hemoglobin. 2008;32(1-2):85-96
pubmed: 18274986
Int J Hematol. 2018 Jan;107(1):55-63
pubmed: 29177643
Blood Rev. 2008 Dec;22 Suppl 2:S14-21
pubmed: 19059052
Blood. 2016 Jun 9;127(23):2809-13
pubmed: 27044621
Pediatr Blood Cancer. 2007 Sep;49(3):329-32
pubmed: 17554789
Biochim Biophys Acta. 2010 Aug;1800(8):760-9
pubmed: 20304033
Acta Haematol. 2008;119(3):133-41
pubmed: 18408362
Magn Reson Med. 2014 Jun;71(6):2215-23
pubmed: 23821350
Blood Cells Mol Dis. 2015 Dec;55(4):304-7
pubmed: 26460251
Am J Hematol. 2017 Jun;92(6):508-514
pubmed: 28247421
Am J Hematol. 2018 Jul;93(7):943-952
pubmed: 29635754
Haematologica. 2004 Oct;89(10):1187-93
pubmed: 15477202
Magn Reson Imaging. 2007 Feb;25(2):228-31
pubmed: 17275618
Crit Rev Oncol Hematol. 2016 Mar;99:261-71
pubmed: 26806144
Blood. 2012 Aug 2;120(5):970-7
pubmed: 22589472
Hematology Am Soc Hematol Educ Program. 2014 Dec 5;2014(1):210-5
pubmed: 25696857
Clin Lymphoma Myeloma. 2009;9 Suppl 3:S305-11
pubmed: 19778858
Blood. 2006 May 1;107(9):3455-62
pubmed: 16352812
Eur J Haematol. 2008 Feb;80(2):168-76
pubmed: 18028431
Blood Cells Mol Dis. 2013 Jan;50(1):20-4
pubmed: 23017692
Annu Rev Med. 2009;60:25-38
pubmed: 19630568
Eur Heart J. 2001 Dec;22(23):2171-9
pubmed: 11913479
Am J Hematol. 2010 Apr;85(4):288-90
pubmed: 20143405
Eur J Haematol. 2017 Mar;98(3):280-288
pubmed: 27859648
Br J Haematol. 2009 Sep;146(5):569-72
pubmed: 19604239
J Clin Oncol. 2010 Jun 10;28(17):2847-52
pubmed: 20421543
Orphanet J Rare Dis. 2014 Sep 30;9:131
pubmed: 25265971
Med Care. 1992 Jun;30(6):473-83
pubmed: 1593914
Haematologica. 2007 May;92(5):583-8
pubmed: 17488680
Haematologica. 2011 Nov;96(11):1605-12
pubmed: 21791471
Blood. 2009 Dec 17;114(26):5251-5
pubmed: 19710499
Curr Med Res Opin. 2009 Jan;25(1):139-47
pubmed: 19210147
J Cardiovasc Magn Reson. 2008 Sep 25;10:42
pubmed: 18817553
Int J Hematol. 2008 Jul;88(1):7-15
pubmed: 18594779
Blood. 2015 Oct 22;126(17):2031-7
pubmed: 26276665
Blood. 1997 Feb 1;89(3):739-61
pubmed: 9028304
Blood. 2012 Mar 22;119(12):2746-53
pubmed: 22279056
Hematology Am Soc Hematol Educ Program. 2009;:215-21
pubmed: 20008201
Leuk Lymphoma. 2017 Nov;58(11):2752-2754
pubmed: 28482720
Blood. 2014 Aug 7;124(6):873-81
pubmed: 24923296
Hematol Oncol Clin North Am. 2014 Aug;28(4):747-64, vii
pubmed: 25064711