Cancer Modeling-on-a-Chip with Future Artificial Intelligence Integration.
artificial intelligence
cancer models
chemotherapy
microfluidics
organ-on-a-chip
Journal
Small (Weinheim an der Bergstrasse, Germany)
ISSN: 1613-6829
Titre abrégé: Small
Pays: Germany
ID NLM: 101235338
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
20
04
2019
revised:
22
07
2019
pubmed:
15
11
2019
medline:
2
10
2020
entrez:
15
11
2019
Statut:
ppublish
Résumé
Cancer is one of the leading causes of death worldwide, despite the large efforts to improve the understanding of cancer biology and development of treatments. The attempts to improve cancer treatment are limited by the complexity of the local milieu in which cancer cells exist. The tumor microenvironment (TME) consists of a diverse population of tumor cells and stromal cells with immune constituents, microvasculature, extracellular matrix components, and gradients of oxygen, nutrients, and growth factors. The TME is not recapitulated in traditional models used in cancer investigation, limiting the translation of preliminary findings to clinical practice. Advances in 3D cell culture, tissue engineering, and microfluidics have led to the development of "cancer-on-a-chip" platforms that expand the ability to model the TME in vitro and allow for high-throughput analysis. The advances in the development of cancer-on-a-chip platforms, implications for drug development, challenges to leveraging this technology for improved cancer treatment, and future integration with artificial intelligence for improved predictive drug screening models are discussed.
Identifiants
pubmed: 31724305
doi: 10.1002/smll.201901985
pmc: PMC6929691
mid: NIHMS1060095
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1901985Subventions
Organisme : NCI NIH HHS
ID : U01 CA214411
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL140951
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB023052
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR066193
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR057837
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB024403
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL140618
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR073135
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM126831
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR069564
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB021857
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137193
Pays : United States
Informations de copyright
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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