Imported severe malaria and risk factors for intensive care: A single-centre retrospective analysis.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
13
06
2019
accepted:
29
10
2019
entrez:
15
11
2019
pubmed:
15
11
2019
medline:
25
3
2020
Statut:
epublish
Résumé
This study aims to identify the risk factors for intensive care (IC) in severe malaria patients admitted to the "Lazzaro Spallanzani" National Institute for Infectious Diseases, Rome, Italy. All patients with confirmed severe malaria and hospitalized between 2007 and 2015 were included in the analysis and stratified into two groups: those requiring IC and those who did not. Five prognostic malaria scores were estimated; clinical severity at IC unit admission was assessed using the Sequential Organ Failure Assessment and the quick-Sequential Organ Failure Assessment scores. Univariate and multivariate analysis were performed to assess factors independently associated to IC. A total of 98 severe malaria patients were included; 10 of them required IC. There were no deaths or sequelae. Patients requiring IC had higher severity scores. At the multivariate analysis, only the number of World Health Organization criteria and the aspartate aminotransferase value were independently associated with the need of IC. An early and accurate assessment of the severity score is essential for the management of severe malaria patients.
Identifiants
pubmed: 31725774
doi: 10.1371/journal.pone.0225135
pii: PONE-D-19-16792
pmc: PMC6855647
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0225135Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Trans R Soc Trop Med Hyg. 1994 May-Jun;88(3):314
pubmed: 7974674
Med Mal Infect. 2020 Mar;50(2):213-225
pubmed: 30266432
Lancet Infect Dis. 2017 Jan;17(1):98-107
pubmed: 27777030
Lancet. 2010 Nov 13;376(9753):1647-57
pubmed: 21062666
Clin Infect Dis. 1998 Jul;27(1):142-9
pubmed: 9675468
J Assoc Physicians India. 2009 Feb;57:119-26
pubmed: 19582979
PLoS One. 2010 Oct 08;5(10):e13236
pubmed: 20949045
JAMA. 2016 Feb 23;315(8):762-74
pubmed: 26903335
Lancet. 2005 Aug 27-Sep 2;366(9487):717-25
pubmed: 16125588
Br J Anaesth. 2014 Dec;113(6):910-21
pubmed: 24946778
Ann Intern Med. 1990 Aug 15;113(4):326-7
pubmed: 2197915
J Assoc Physicians India. 2014 Jan;62(1):14-7
pubmed: 25327086
Acta Trop. 2015 Jun;146:152-6
pubmed: 25820030
Intensive Care Med. 1996 Jul;22(7):707-10
pubmed: 8844239
Malar J. 2007 Feb 27;6:24
pubmed: 17326839
Clin Infect Dis. 2010 Mar 1;50(5):679-85
pubmed: 20105074