Nonarteritic anterior ischemic optic neuropathy is associated with cerebral small vessel disease.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
09
08
2019
accepted:
01
11
2019
entrez:
15
11
2019
pubmed:
15
11
2019
medline:
25
3
2020
Statut:
epublish
Résumé
We investigated the presence of cerebral small vessel disease (SVD) in patients with nonarteritic anterior ischemic optic neuropathy (NAION) compared to control subjects without NAION to identify the association between NAION and cerebral SVD. We retrospectively reviewed the cases of 63 patients with NAION and 2749 control subjects without any neurologic and ocular diseases including NAION who underwent careful medical interviews, ophthalmic examinations, and magnetic resonance imaging (MRI) studies of the brain. We assessed and compared the degree of cerebral SVD on the MRIs. The patients with NAION presented with cerebral SVD more frequently than controls (68% versus 37%, respectively, p<0.001), which was also observed after adjusting for age, sex, comorbid conditions including hypertension, diabetes, and dyslipidemia, and smoking using the standardized mortality ratio (68% vs. 37%, p<0.001). A multivariate logistic regression analysis showed that the odds of cerebral SVD were 4.86 (95% CI, 2.10 to 11.24, p<0.001) times higher in patients with NAION than in the controls. We found that there was an association between cerebral SVD and NAION even after adjusting for age, sex, and medical histories. Clinicians should consider brain MRI scans in patients with NAION to prevent neurological impairment after cerebral SVD.
Identifiants
pubmed: 31725805
doi: 10.1371/journal.pone.0225322
pii: PONE-D-19-22516
pmc: PMC6855457
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0225322Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Am J Ophthalmol. 2016 Oct;170:183-189
pubmed: 27521605
Am J Ophthalmol. 1994 Feb 15;117(2):222-30
pubmed: 8116751
Neuroepidemiology. 2013;40(3):220-4
pubmed: 23364133
Am J Ophthalmol. 1994 Dec 15;118(6):766-80
pubmed: 7977604
BMC Neurol. 2011 Feb 28;11:29
pubmed: 21356112
J Clin Neurosci. 2009 Aug;16(8):994-1000
pubmed: 19596112
Clin Neurol Neurosurg. 2011 Apr;113(3):177-80
pubmed: 21094582
AJR Am J Roentgenol. 1987 Aug;149(2):351-6
pubmed: 3496763
J Neuroophthalmol. 2003 Jun;23(2):157-63
pubmed: 12782932
Eur Radiol. 2007 Jul;17(7):1669-74
pubmed: 17131125
Am J Ophthalmol. 2017 Mar;175:213-214
pubmed: 28093100
Lancet Neurol. 2013 May;12(5):483-97
pubmed: 23602162
Lancet Neurol. 2009 Feb;8(2):165-74
pubmed: 19161908
Invest Ophthalmol Vis Sci. 2017 May 1;58(6):BIO82-BIO87
pubmed: 28525562
J Neuroophthalmol. 1995 Sep;15(3):158-60
pubmed: 8574360
Lancet Neurol. 2010 Jul;9(7):689-701
pubmed: 20610345
Stroke. 2014 Nov;45(11):3461-71
pubmed: 25293663
Invest Ophthalmol Vis Sci. 2016 Oct 1;57(13):5818-5824
pubmed: 27802487
Eye (Lond). 2015 Jan;29(1):65-79
pubmed: 24993324
Lancet Neurol. 2013 Aug;12(8):735-6
pubmed: 23867194
Br J Ophthalmol. 2006 Nov;90(11):1350-3
pubmed: 16825277
CNS Neurosci Ther. 2012 Jun;18(6):452-6
pubmed: 22268862
Stroke Vasc Neurol. 2016 Oct 25;1(3):83-92
pubmed: 28959468
Neurology. 2006 May 9;66(9):1335-8
pubmed: 16682663
Brain. 2007 Aug;130(Pt 8):1988-2003
pubmed: 17322562