Reduction of fibrillar strain-rate sensitivity in steroid-induced osteoporosis linked to changes in mineralized fibrillar nanostructure.

Animals Bone Matrix Bone and Bones Mice Nanostructures Osteoporosis / chemically induced Steroids Stress, Mechanical
Glucocorticoid induced osteoporosis Multiscale Mechanical modelling Nanoscale deformation mechanisms Synchrotron X-ray nanomechanical imaging

Journal

Bone
ISSN: 1873-2763
Titre abrégé: Bone
Pays: United States
ID NLM: 8504048

Informations de publication

Date de publication:
02 2020
Historique:
received: 16 07 2019
revised: 13 10 2019
accepted: 15 10 2019
pubmed: 15 11 2019
medline: 22 6 2021
entrez: 15 11 2019
Statut: ppublish

Résumé

As bone is used in a dynamic mechanical environment, understanding the structural origins of its time-dependent mechanical behaviour - and the alterations in metabolic bone disease - is of interest. However, at the scale of the mineralized fibrillar matrix (nanometre-level), the nature of the strain-rate dependent mechanics is incompletely understood. Here, we investigate the fibrillar- and mineral-deformation behaviour in a murine model of Cushing's syndrome, used to understand steroid induced osteoporosis, using synchrotron small- and wide-angle scattering/diffraction combined with in situ tensile testing at three strain rates ranging from 10

Identifiants

DOI: 10.1016/j.bone.2019.115111 PMID: 31726107
pubmed: 31726107
pii: S8756-3282(19)30404-1
doi: 10.1016/j.bone.2019.115111
pii:
doi:

Substances chimiques

Steroids 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

115111

Subventions

Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/R004773/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R025673/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0600702
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/R003610/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U142661184
Pays : United Kingdom

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

L Xi (L)

Institute of Advanced Structure Technology, Beijing Institute of Technology, Beijing 100081, China; School of Engineering and Material Sciences, Queen Mary University of London, London, E1 4NS, UK. Electronic address: xili@bit.edu.cn.

P De Falco (P)

School of Engineering and Material Sciences, Queen Mary University of London, London, E1 4NS, UK; Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, D-14424 Potsdam-Golm, Germany. Electronic address: paolino.defalco@mpikg.mpg.de.

E Barbieri (E)

School of Engineering and Material Sciences, Queen Mary University of London, London, E1 4NS, UK; Department of Mathematical Science and Advanced Technology (MAT), Yokohama Institute for Earth Sciences (YES) 3173-25, Showa-machi, Kanazawa-ku, Yokohama-city, Japan. Electronic address: e.barbieri@jamstec.go.jp.

A Karunaratne (A)

Department of Mechanical Engineering, University of Moratuwa, Sri Lanka. Electronic address: angelok@uom.lk.

L Bentley (L)

MRC Mammalian Genetics Unit and Mary Lyon Centre, MRC Harwell, Harwell Science and Innovation Campus, OX11 0RD, UK. Electronic address: l.bentley@har.mrc.ac.uk.

C T Esapa (CT)

MRC Mammalian Genetics Unit and Mary Lyon Centre, MRC Harwell, Harwell Science and Innovation Campus, OX11 0RD, UK; Academic Endocrine Unit, Radcliffe Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Churchill Hospital, Headington, Oxford, OX3 7JL, UK. Electronic address: c.esapa@har.mrc.ac.uk.

G R Davis (GR)

Dental Physical Sciences Unit, Queen Mary University of London, London, E1 4NS, UK. Electronic address: g.r.davis@qmul.ac.uk.

N J Terrill (NJ)

Beamline I22, Diamond Light Source Ltd., Diamond House, Harwell Science and Innovation Campus, Chilton, Didcot, Oxfordshire, OX11 0DE, United Kingdom.

R D Cox (RD)

MRC Mammalian Genetics Unit and Mary Lyon Centre, MRC Harwell, Harwell Science and Innovation Campus, OX11 0RD, UK. Electronic address: r.cox@har.mrc.ac.uk.

N M Pugno (NM)

Laboratory of Bio-Inspired & Graphene Nanomechanics, Department of Civil, Environmental and Mechanical Engineering, University of Trento, Via Mesiano, 77, 38123, Trento, Italy; School of Engineering and Material Sciences, Queen Mary University of London, London, E1 4NS, UK; Ket Lab, Edoardo Amaldi Foundation, Via del Politecnico snc, 00133, Rome, Italy. Electronic address: nicola.pugno@unitn.it.

R V Thakker (RV)

Academic Endocrine Unit, Radcliffe Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Churchill Hospital, Headington, Oxford, OX3 7JL, UK. Electronic address: rajesh.thakker@ndm.ox.ac.uk.

R Weinkamer (R)

Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, D-14424 Potsdam-Golm, Germany. Electronic address: richard.weinkamer@mpikg.mpg.de.

W W Wu (WW)

Institute of Advanced Structure Technology, Beijing Institute of Technology, Beijing 100081, China. Electronic address: wuwenwang@bit.edu.cn.

D N Fang (DN)

Institute of Advanced Structure Technology, Beijing Institute of Technology, Beijing 100081, China; State Key Laboratory for Turbulence and Complex Systems, College of Engineering, Peking University, Beijing, China. Electronic address: fangdn@bit.edu.cn.

H S Gupta (HS)

School of Engineering and Material Sciences, Queen Mary University of London, London, E1 4NS, UK. Electronic address: h.gupta@qmul.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Reduction of fibrillar strain-rate sensitivity...
questionsmedicales.fr › Tissus › Tissu conjonctif › Os et tissu osseux › Trame osseuse › Reduction of fibrillar strain-rate sensitivity...
questionsmedicales.fr › Tissus › Tissu conjonctif › Os et tissu osseux › Reduction of fibrillar strain-rate sensitivity...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Reduction of fibrillar strain-rate sensitivity...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Reduction of fibrillar strain-rate sensitivity...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Maladies osseuses métaboliques › Ostéoporose › Reduction of fibrillar strain-rate sensitivity...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Reduction of fibrillar strain-rate sensitivity...
questionsmedicales.fr › Phénomènes physiques › Phénomènes mécaniques › Contrainte mécanique › Reduction of fibrillar strain-rate sensitivity...