Claudin-2: Roles beyond Permeability Functions.
cancer
claudin-2
epithelium
fibrosis
inflammation
migration
paracellular permeability
proliferation
tight junctions
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 Nov 2019
12 Nov 2019
Historique:
received:
13
10
2019
revised:
08
11
2019
accepted:
09
11
2019
entrez:
16
11
2019
pubmed:
16
11
2019
medline:
2
4
2020
Statut:
epublish
Résumé
Claudin-2 is expressed in the tight junctions of leaky epithelia, where it forms cation-selective and water permeable paracellular channels. Its abundance is under fine control by a complex signaling network that affects both its synthesis and turnover in response to various environmental inputs. Claudin-2 expression is dysregulated in many pathologies including cancer, inflammation, and fibrosis. Claudin-2 has a key role in energy-efficient ion and water transport in the proximal tubules of the kidneys and in the gut. Importantly, strong evidence now also supports a role for this protein as a modulator of vital cellular events relevant to diseases. Signaling pathways that are overactivated in diseases can alter claudin-2 expression, and a good correlation exists between disease stage and claudin-2 abundance. Further, loss- and gain-of-function studies showed that primary changes in claudin-2 expression impact vital cellular processes such as proliferation, migration, and cell fate determination. These effects appear to be mediated by alterations in key signaling pathways. The specific mechanisms linking claudin-2 to these changes remain poorly understood, but adapters binding to the intracellular portion of claudin-2 may play a key role. Thus, dysregulation of claudin-2 may contribute to the generation, maintenance, and/or progression of diseases through both permeability-dependent and -independent mechanisms. The aim of this review is to provide an overview of the properties, regulation, and functions of claudin-2, with a special emphasis on its signal-modulating effects and possible role in diseases.
Identifiants
pubmed: 31726679
pii: ijms20225655
doi: 10.3390/ijms20225655
pmc: PMC6888627
pii:
doi:
Substances chimiques
CLDN2 protein, human
0
Claudins
0
Neoplasm Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CIHR
ID : PJT-149058
Pays : Canada
Organisme : CIHR
ID : MOP-142409
Pays : Canada
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : RGPIN-2017-06517
Organisme : Kidney Foundation of Canada
ID : n/a
Références
Tissue Barriers. 2018;6(3):1539596
pubmed: 30395792
Histol Histopathol. 2008 Jun;23(6):673-82
pubmed: 18366005
Cancer Res. 2018 Jun 1;78(11):2925-2938
pubmed: 29510994
Nat Genet. 1999 Mar;21(3):326-9
pubmed: 10080190
J Cell Biol. 2013 Nov 25;203(4):605-14
pubmed: 24385485
J Cell Sci. 2010 Jun 1;123(Pt 11):1913-21
pubmed: 20460438
Oncol Rep. 2016 Dec;36(6):3087-3094
pubmed: 27748858
J Pharmacol Exp Ther. 2017 Dec;363(3):444-451
pubmed: 28928120
Lab Invest. 2008 Oct;88(10):1110-20
pubmed: 18711353
J Cell Physiol. 2005 Apr;203(1):15-26
pubmed: 15389642
Am J Physiol Cell Physiol. 2004 Aug;287(2):C327-35
pubmed: 15044152
Biochim Biophys Acta. 2014 Sep;1843(9):2079-88
pubmed: 24907662
Biochim Biophys Acta. 2012 Jun;1823(6):1110-8
pubmed: 22546605
Int J Med Sci. 2018 Feb 5;15(4):339-351
pubmed: 29511369
Dig Dis Sci. 2013 Jun;58(6):1546-59
pubmed: 23306855
Toxicol Mech Methods. 2014 Oct;24(7):520-8
pubmed: 25052570
Mol Biol Cell. 2006 Aug;17(8):3569-77
pubmed: 16723500
Sci Rep. 2019 Mar 13;9(1):4323
pubmed: 30867502
Am J Physiol Cell Physiol. 2012 Dec 15;303(12):C1278-91
pubmed: 23076790
J Cell Biol. 1998 Oct 19;143(2):391-401
pubmed: 9786950
Oncology. 2007;73(5-6):357-65
pubmed: 18500171
Gastroenterology. 2011 Mar;140(3):913-23
pubmed: 20727355
J Am Soc Nephrol. 2017 Aug;28(8):2459-2471
pubmed: 28428333
Genome Biol. 2009;10(8):235
pubmed: 19706201
Biochem Biophys Res Commun. 2004 Feb 20;314(4):1001-7
pubmed: 14751232
J Biol Chem. 2014 Mar 7;289(10):6475-84
pubmed: 24436330
Biochim Biophys Acta. 2008 Mar;1778(3):601-13
pubmed: 18339298
J Cell Physiol. 2015 Jan;230(1):105-15
pubmed: 24909426
Ann N Y Acad Sci. 2017 Jun;1397(1):100-109
pubmed: 28636801
Nutrients. 2015 Jun 08;7(6):4578-92
pubmed: 26061016
Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20591-6
pubmed: 22143774
J Surg Res. 2011 May 15;167(2):e185-91
pubmed: 20462599
Gastroenterology. 2013 Feb;144(2):369-80
pubmed: 23089202
Int J Mol Sci. 2019 Oct 02;20(19):null
pubmed: 31581662
J Cell Physiol. 2011 Jun;226(6):1471-8
pubmed: 20717932
J Cell Biol. 1999 Nov 15;147(4):891-903
pubmed: 10562289
Am J Physiol Cell Physiol. 2018 Mar 1;314(3):C366-C378
pubmed: 29187366
J Clin Invest. 2016 Jul 1;126(7):2509-18
pubmed: 27214555
Ann N Y Acad Sci. 2012 Jul;1258:9-18
pubmed: 22731710
Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):8011-6
pubmed: 20385797
Int Rev Cell Mol Biol. 2014;308:205-71
pubmed: 24411173
Am J Physiol Cell Physiol. 2003 Jun;284(6):C1346-54
pubmed: 12700140
FEBS Lett. 2011 Feb 18;585(4):606-12
pubmed: 21276448
Cancer Cell Int. 2018 Oct 17;18:160
pubmed: 30349422
PLoS One. 2014 Mar 24;9(3):e85345
pubmed: 24662742
Anticancer Res. 2014 Aug;34(8):4181-7
pubmed: 25075044
Oncotarget. 2015 Apr 20;6(11):9476-87
pubmed: 25823815
Cold Spring Harb Perspect Biol. 2010 Jan;2(1):a002907
pubmed: 20182608
Mol Biol Cell. 2014 Sep 15;25(18):2710-9
pubmed: 25031428
Mol Biol Cell. 2009 Sep;20(17):3930-40
pubmed: 19605556
J Biol Chem. 2006 Nov 24;281(47):36117-23
pubmed: 17018523
J Biol Chem. 2004 Jan 30;279(5):3543-52
pubmed: 14593119
Cell Tissue Res. 2009 Apr;336(1):67-77
pubmed: 19214581
Semin Cell Dev Biol. 2015 Jun;42:22-9
pubmed: 25957515
J Biol Chem. 2002 Jun 14;277(24):21361-70
pubmed: 11934881
Annu Rev Physiol. 2011;73:283-309
pubmed: 20936941
Cancer Metastasis Rev. 2016 Dec;35(4):645-654
pubmed: 27878502
Am J Physiol Renal Physiol. 2013 Nov 1;305(9):F1352-64
pubmed: 24049145
Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2628-33
pubmed: 20133805
Ann N Y Acad Sci. 2012 Jul;1258:60-4
pubmed: 22731716
Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4690-4
pubmed: 15070779
J Biol Chem. 2011 Sep 9;286(36):31263-71
pubmed: 21771795
J Gen Physiol. 2009 Jan;133(1):111-27
pubmed: 19114638
Mediators Inflamm. 2017;2017:9621724
pubmed: 28260841
Pancreatology. 2015 Jul;15(4 Suppl):S23-31
pubmed: 26149858
Am J Physiol Cell Physiol. 2015 Jul 1;309(1):C38-50
pubmed: 25948735
Cell Immunol. 2013 Nov-Dec;286(1-2):22-30
pubmed: 24287273
Carcinogenesis. 2008 Oct;29(10):1994-2000
pubmed: 18586689
Am J Physiol Cell Physiol. 2019 Jan 1;316(1):C33-C47
pubmed: 30207785
Scand J Gastroenterol. 2010 Nov;45(11):1273-80
pubmed: 20602571
J Comp Physiol B. 2010 Apr;180(4):591-8
pubmed: 20049600
Elife. 2015 Nov 14;4:e09906
pubmed: 26568313
Scand J Immunol. 2012 Jun;75(6):588-98
pubmed: 22268650
F1000Res. 2016 Apr 19;5:
pubmed: 27134739
Pflugers Arch. 2017 Aug;469(7-8):877-887
pubmed: 28600680
Int J Biochem Cell Biol. 2012 Jan;44(1):178-88
pubmed: 22062948
Am J Physiol Cell Physiol. 2007 Nov;293(5):C1660-8
pubmed: 17855771
J Membr Biol. 2004 May 1;199(1):29-38
pubmed: 15366421
J Cell Sci. 2012 Oct 15;125(Pt 20):4902-12
pubmed: 22825868
Am J Physiol Cell Physiol. 2013 Jul 15;305(2):C190-6
pubmed: 23677799
Growth Factors. 2012 Oct;30(5):320-32
pubmed: 22946653
Biochim Biophys Acta Mol Cell Res. 2018 Mar;1865(3):470-479
pubmed: 29247669
Eur J Pharm Sci. 2018 May 30;117:161-167
pubmed: 29448044
Ann N Y Acad Sci. 2012 Jul;1258:34-42
pubmed: 22731713
Expert Rev Mol Med. 2010 May 27;12:e17
pubmed: 20504380
J Biol Chem. 2019 Oct 18;294(42):15446-15465
pubmed: 31481470
J Cell Biol. 2010 Apr 5;189(1):111-26
pubmed: 20351069
Cancer Res. 2017 Sep 15;77(18):4809-4822
pubmed: 28754672
FASEB J. 2008 Jan;22(1):146-58
pubmed: 17761522
Development. 2016 Dec 1;143(23):4291-4300
pubmed: 27899506
Sci Rep. 2018 Oct 19;8(1):15550
pubmed: 30341325
Acta Physiol (Oxf). 2017 Feb;219(2):521-536
pubmed: 27359349
Life Sci. 2011 Mar 28;88(13-14):628-33
pubmed: 21315735
Dig Dis Sci. 2018 Apr;63(4):910-919
pubmed: 29427225
Nutrients. 2017 Jun 13;9(6):null
pubmed: 28608828
Mol Oncol. 2014 Feb;8(1):119-28
pubmed: 24287398
Am J Physiol Renal Physiol. 2010 Mar;298(3):F672-82
pubmed: 19955189
Virchows Arch. 2018 Mar;472(3):395-405
pubmed: 29134439
J Mol Biol. 2008 Sep 5;381(3):681-91
pubmed: 18635194
J Cell Biol. 1998 Jun 29;141(7):1539-50
pubmed: 9647647
Tissue Barriers. 2015 Apr 03;3(1-2):e977176
pubmed: 25838982
Sci Rep. 2019 Mar 21;9(1):4982
pubmed: 30899070
Gastroenterology. 2014 Nov;147(5):1134-45.e10
pubmed: 25068494
Histopathology. 2008 Jul;53(1):48-55
pubmed: 18479414
Virchows Arch. 2006 Apr;448(4):428-34
pubmed: 16328347
Pflugers Arch. 2017 Jan;469(1):15-26
pubmed: 27904960
Int J Mol Sci. 2017 Jan 17;18(1):
pubmed: 28106723
Biochim Biophys Acta Mol Cell Res. 2017 Oct;1864(10):1714-1733
pubmed: 28554775
Clin Genet. 2010 Apr;77(4):314-25
pubmed: 20447145
Ann N Y Acad Sci. 2012 Jun;1257:103-7
pubmed: 22671595
Nat Rev Mol Cell Biol. 2016 Sep;17(9):564-80
pubmed: 27353478
Lung Cancer. 2007 Aug;57(2):159-67
pubmed: 17418912
Oncogene. 2011 Jul 21;30(29):3234-47
pubmed: 21383692
J Biol Chem. 2016 Nov 18;291(47):24787-24799
pubmed: 27733684
Am J Physiol Renal Physiol. 2007 Nov;293(5):F1714-26
pubmed: 17881458
J Biol Chem. 2011 Feb 4;286(5):3442-50
pubmed: 21098027
J Biol Chem. 2005 Feb 4;280(5):3780-8
pubmed: 15569684
J Cell Physiol. 2015 Nov;230(11):2776-87
pubmed: 25825272
Semin Cell Dev Biol. 2014 Dec;36:157-65
pubmed: 25171873
J Membr Biol. 2007 Feb;215(2-3):147-59
pubmed: 17516019
Biol Pharm Bull. 2009 May;32(5):825-31
pubmed: 19420749
J Biol Chem. 2017 Feb 10;292(6):2411-2421
pubmed: 28057758
J Cutan Pathol. 2014 Aug;41(8):630-9
pubmed: 24995964
Mucosal Immunol. 2014 Nov;7(6):1340-53
pubmed: 24670427
Mol Biol Cell. 2015 Apr 15;26(8):1523-31
pubmed: 25694446
Tissue Barriers. 2017 Apr 3;5(2):e1327839
pubmed: 28548895
Nat Cell Biol. 2016 Jun 28;18(7):711-7
pubmed: 27350441
Diagn Pathol. 2013 Aug 06;8:133
pubmed: 23919729
Oncogene. 2013 Oct 10;32(41):4873-82
pubmed: 23160379
Proteins. 2006 Dec 1;65(4):808-15
pubmed: 17022085
Am J Physiol Renal Physiol. 2009 Sep;297(3):F604-11
pubmed: 19587148
Mol Cell Biol. 2012 Aug;32(15):2979-91
pubmed: 22645303
Pflugers Arch. 2017 Jan;469(1):105-113
pubmed: 27878608
Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):2326-36
pubmed: 26163137
Physiol Rev. 2013 Apr;93(2):525-69
pubmed: 23589827
Ann N Y Acad Sci. 2017 Oct;1405(1):44-52
pubmed: 28869648
Genes Dev. 2019 Feb 1;33(3-4):180-193
pubmed: 30692208
Biochim Biophys Acta. 2014 Feb;1838(2):595-604
pubmed: 23867773
Curr Cancer Drug Targets. 2013 Nov;13(9):963-972
pubmed: 24168186
Curr Opin Cell Biol. 2016 Oct;42:94-101
pubmed: 27236618
Biosci Rep. 2018 Nov 28;38(6):
pubmed: 30369485
Neuroreport. 2000 May 15;11(7):1427-31
pubmed: 10841351
Free Radic Biol Med. 2009 Dec 1;47(11):1561-9
pubmed: 19733232
Mol Carcinog. 2009 Jun;48(6):488-97
pubmed: 18942115
Hum Pathol. 2004 Dec;35(12):1531-6
pubmed: 15619213
Oncotarget. 2017 Sep 23;8(50):87718-87736
pubmed: 29152115
Sci Rep. 2015 Jul 27;5:10642
pubmed: 26212084
J Cell Biol. 1999 Dec 13;147(6):1351-63
pubmed: 10601346
Biochim Biophys Acta. 2008 Mar;1778(3):660-9
pubmed: 17854762
Gut. 2007 Jan;56(1):61-72
pubmed: 16822808
J Biol Chem. 2015 Mar 13;290(11):7234-46
pubmed: 25616664
Free Radic Biol Med. 2014 Jul;72:162-75
pubmed: 24726862
J Cell Biol. 2001 Apr 16;153(2):263-72
pubmed: 11309408
PLoS One. 2013;8(3):e58606
pubmed: 23505542
Gastroenterology. 2000 Jun;118(6):1001-11
pubmed: 10833473
Anticancer Res. 2007 Nov-Dec;27(6A):3729-34
pubmed: 17970035
Biochim Biophys Acta. 2008 Mar;1778(3):631-45
pubmed: 18036336
Sci Rep. 2016 Nov 09;6:36776
pubmed: 27827449
J Biol Chem. 2006 Aug 4;281(31):22299-311
pubmed: 16737968
Compr Physiol. 2012 Jul;2(3):1819-52
pubmed: 23723025
World J Gastroenterol. 2016 Mar 21;22(11):3117-26
pubmed: 27003989
J Cell Sci. 2002 Dec 15;115(Pt 24):4969-76
pubmed: 12432083
PLoS One. 2015 Jul 06;10(7):e0131416
pubmed: 26146837
Am J Physiol Cell Physiol. 2002 Jul;283(1):C142-7
pubmed: 12055082
BMC Cancer. 2012 Jul 23;12:309
pubmed: 22824143
Oncogene. 2011 Mar 17;30(11):1318-28
pubmed: 21076473
Int J Mol Sci. 2013 Sep 04;14(9):18148-80
pubmed: 24009024
PLoS One. 2012;7(3):e28659
pubmed: 22396724
J Cell Physiol. 2011 Sep;226(9):2448-56
pubmed: 21660968
J Immunol. 2017 Nov 1;199(9):3316-3325
pubmed: 28939759
PLoS One. 2015 May 06;10(5):e0124835
pubmed: 25946026
Am J Physiol Cell Physiol. 2005 Oct;289(4):C1002-14
pubmed: 15930145
Trends Biochem Sci. 2019 Feb;44(2):141-152
pubmed: 30665499
J Biol Chem. 2015 Jul 3;290(27):16595-606
pubmed: 26023235
Cancer Biol Ther. 2004 Jul;3(7):593-601
pubmed: 15136761
J Cell Sci. 2010 Dec 1;123(Pt 23):4145-55
pubmed: 21062898
Am J Physiol Gastrointest Liver Physiol. 2000 Nov;279(5):G851-7
pubmed: 11052980