Increased Paracetamol Bioavailability after Sleeve Gastrectomy: A Crossover Pre- vs. Post-Operative Clinical Trial.

bariatric surgery drug absorption gastric emptying glucuronidation laparoscopic sleeve gastrectomy paracetamol (acetaminophen)

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
12 Nov 2019
Historique:
received: 24 09 2019
revised: 03 11 2019
accepted: 08 11 2019
entrez: 16 11 2019
pubmed: 16 11 2019
medline: 16 11 2019
Statut: epublish

Résumé

Oral drug bioavailability may be significantly altered after laparoscopic sleeve gastrectomy (LSG), the most popular bariatric procedure worldwide. Paracetamol (acetaminophen) is the post-bariatric analgesic/antipyretic drug of choice. In this work we studied and analyzed the LSG effects on systemic bioavailability and pharmacokinetics of paracetamol after oral administration of solid vs. liquid dosage form. A 4-armed, pharmacokinetic, crossover trial was performed in patients enrolled for LSG. Single paracetamol dose (500 mg), as caplet (

Identifiants

pubmed: 31726725
pii: jcm8111949
doi: 10.3390/jcm8111949
pmc: PMC6912358
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Daniel Porat (D)

Department of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.

Milica Markovic (M)

Department of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.

Moran Zur (M)

Department of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.

Noa Fine-Shamir (N)

Department of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.

Carmil Azran (C)

Clinical Pharmacy, Herzliya Medical Center, Herzliya 46140, Israel.

Gad Shaked (G)

Department of Surgery B, Soroka University Medical Center, Beer Sheva 84101, Israel.

David Czeiger (D)

Department of Surgery B, Soroka University Medical Center, Beer Sheva 84101, Israel.

Julie Vaynshtein (J)

Department of Surgery B, Soroka University Medical Center, Beer Sheva 84101, Israel.

Ilya Replyanski (I)

Department of Surgery B, Soroka University Medical Center, Beer Sheva 84101, Israel.

Gilbert Sebbag (G)

Department of Surgery B, Soroka University Medical Center, Beer Sheva 84101, Israel.

Arik Dahan (A)

Department of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.

Classifications MeSH