Modification of the risk of post-traumatic stress disorder (PTSD) by the 5-HTTLPR polymorphisms after Lorca's earthquakes (Murcia, Spain).
Adult
Anxiety Disorders
/ genetics
Cross-Sectional Studies
Earthquakes
Female
Gene-Environment Interaction
Genotype
Humans
Logistic Models
Male
Middle Aged
Natural Disasters
Polymorphism, Genetic
Risk Factors
Serotonin Plasma Membrane Transport Proteins
/ genetics
Spain
Stress Disorders, Post-Traumatic
/ genetics
Young Adult
5-HTTLPR polymorphisms
Gene-environment interaction
Post-traumatic stress disorder
Journal
Psychiatry research
ISSN: 1872-7123
Titre abrégé: Psychiatry Res
Pays: Ireland
ID NLM: 7911385
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
09
07
2019
revised:
13
10
2019
accepted:
24
10
2019
pubmed:
16
11
2019
medline:
29
4
2020
entrez:
16
11
2019
Statut:
ppublish
Résumé
Information of the modulation effect of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) on post-traumatic stress disorder (PTSD) after earthquakes is scarce and contradictory. A cross-sectional face-to-face interview survey of a representative sample of the adults was carried out after the Lorca (Spain) earthquakes (May 11, 2011). Socio-demographic variables, DSM-IV diagnostic assessment and earthquake-related stressors were obtained from the Composite International Diagnostic Interview (CIDI). The triallelic and biallelic classification of the 5-HTTLPR polymorphism were genotyped from buccal swabs. Multivariate logistic regression models were used to predict PTSD, including interaction terms to explore gene-environment (G x E) interactions. The vast majority (83%, n = 341) of the Lorca survey respondents (n = 412, 71% response rate) were genotyped. Both classifications of the 5-HTTLPR genotype were in Hardy-Weinberg equilibrium. Prior lifetime PTSD was the only variable that remained a significant predictor after adjustments. There were no significant main effects of earthquake related stressors or 5-HTTLPR. However, G x E interactions of 5-HTTLPR with high emotional impact and prior lifetime anxiety disorders were statistically significant. These results provide new evidence of the modulation effect of the 5-HTTLPR polymorphisms on PTSD risk. This information might characterize people at higher risk of developing PTSD after an earthquake exposure.
Identifiants
pubmed: 31727442
pii: S0165-1781(19)31466-0
doi: 10.1016/j.psychres.2019.112640
pmc: PMC7436333
mid: NIHMS1617625
pii:
doi:
Substances chimiques
SLC6A4 protein, human
0
Serotonin Plasma Membrane Transport Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
112640Subventions
Organisme : NIDA NIH HHS
ID : R01 DA016558
Pays : United States
Organisme : FIC NIH HHS
ID : R03 TW006481
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH069864
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH070884
Pays : United States
Organisme : NIMH NIH HHS
ID : R13 MH066849
Pays : United States
Informations de copyright
Copyright © 2019. Published by Elsevier B.V.
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