Indole-based melatonin analogues: Synthetic approaches and biological activity.
Chemical synthesis
Derivatization
Melatonin analogues
Melatonin receptors
Melatoninergic ligands
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
01 Jan 2020
01 Jan 2020
Historique:
received:
29
08
2019
revised:
01
11
2019
accepted:
01
11
2019
pubmed:
16
11
2019
medline:
19
2
2020
entrez:
16
11
2019
Statut:
ppublish
Résumé
Melatonin is a natural hormone primarily released by the pineal gland that regulates the sleep-wake cycles. The diverse biological applications of melatonin, together with the need to develop new melatoninergic ligands, have stimulated the preparation of a wide range of melatonin derivatives. Here, all the synthetic approaches to indole-based melatonin analogues as well as their biological applications are reviewed. The modifications which have been performed on the melatonin's indole ring and the effects of these modifications on the biological activities have been analysed, detailing the binding affinity of the derivatives for melatonin receptors.
Identifiants
pubmed: 31727472
pii: S0223-5234(19)30999-7
doi: 10.1016/j.ejmech.2019.111847
pii:
doi:
Substances chimiques
Indoles
0
Ligands
0
Receptors, Melatonin
0
Melatonin
JL5DK93RCL
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
111847Informations de copyright
Copyright © 2019 Elsevier Masson SAS. All rights reserved.