Genomics and Targeted Therapies in Gastroesophageal Adenocarcinoma.
Journal
Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
26
04
2019
revised:
09
08
2019
accepted:
06
09
2019
pubmed:
16
11
2019
medline:
8
8
2020
entrez:
16
11
2019
Statut:
ppublish
Résumé
Gastroesophageal adenocarcinomas (GEA) are devastating diseases with stark global presence. Over the past 10 years, there have been minimal improvements in treatment approach despite numerous clinical trials. Here, we review recent progress toward understanding the molecular features of these cancers and the diagnostic and therapeutic challenges posed by their intrinsic genomic instability and heterogeneity. We highlight the potential of genomic heterogeneity to influence clinical trial outcomes for targeted therapies and emphasize the need for comprehensive molecular profiling to guide treatment selection and adapt treatment to resistance and genomic evolution. Revising our clinical approach to GEA by leveraging genomic advances will be integral to the success of current and future treatments, especially as novel targets become therapeutically tractable. SIGNIFICANCE: GEAs are deadly cancers with few treatment options. Characterization of the genomic landscape of these cancers has revealed considerable genetic diversity and spatial heterogeneity. Understanding these fundamental properties of GEA will be critical for overcoming barriers to the development of novel, more effective therapeutic strategies.
Identifiants
pubmed: 31727671
pii: 2159-8290.CD-19-0487
doi: 10.1158/2159-8290.CD-19-0487
pmc: PMC7232941
mid: NIHMS1587586
doi:
Substances chimiques
Antineoplastic Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1656-1672Subventions
Organisme : NCI NIH HHS
ID : P01 CA098101
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA224428
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA127003
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
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