Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy.
Animals
Autoimmune Diseases
/ complications
B-Lymphocytes
/ immunology
Bacteroides
/ immunology
CD4-Positive T-Lymphocytes
/ immunology
Cardiomyopathy, Dilated
/ immunology
Disease Models, Animal
Gastrointestinal Microbiome
/ immunology
Humans
Intestines
/ microbiology
Mice
Mice, Inbred BALB C
Mice, Transgenic
Myocarditis
/ complications
Myosin Heavy Chains
/ genetics
Peptides
/ immunology
Th17 Cells
/ immunology
beta-Galactosidase
/ immunology
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
15 11 2019
15 11 2019
Historique:
received:
07
09
2018
revised:
13
06
2019
accepted:
09
10
2019
entrez:
16
11
2019
pubmed:
16
11
2019
medline:
18
4
2020
Statut:
ppublish
Résumé
Myocarditis can develop into inflammatory cardiomyopathy through chronic stimulation of myosin heavy chain 6-specific T helper (T
Identifiants
pubmed: 31727837
pii: 366/6467/881
doi: 10.1126/science.aav3487
doi:
Substances chimiques
Myh6 protein, mouse
0
Peptides
0
beta-Galactosidase
EC 3.2.1.23
Myosin Heavy Chains
EC 3.6.4.1
Banques de données
figshare
['figshare.com/s/229fc19d6d8db36ad1db']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
881-886Subventions
Organisme : Swiss National Science Foundation
Pays : Switzerland
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.