Preliminary evaluation of dynamic glucose enhanced MRI of the human placenta during glucose tolerance test.
Dynamic glucose enhancement
MRI
glucose chemical exchange saturation transfer (GlucoCEST)
placental function
Journal
Quantitative imaging in medicine and surgery
ISSN: 2223-4292
Titre abrégé: Quant Imaging Med Surg
Pays: China
ID NLM: 101577942
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
entrez:
16
11
2019
pubmed:
16
11
2019
medline:
16
11
2019
Statut:
ppublish
Résumé
To investigate dynamic glucose enhanced (DGE) chemical exchange saturation transfer (CEST) MRI as a means to non-invasively image glucose transport in the human placenta. Continuous wave (CW) CEST MRI was performed at 3.0 Tesla. The glucose contrast enhancement (GCE) was calculated based on the magnetization transfer asymmetry (MTRasym), and the DGE was calculated with the positive side of Z-spectra in reference to the first time point. The glucose CEST (GlucoCEST) was optimized using a glucose solution phantom. Glucose solution perfused The GCE effect peaks at a saturation B1 field of about 2 μT, and the GlucoCEST effect increases linearly with the glucose concentration between 4-20 mM. In Despite the challenges of placental motion and field inhomogeneity, our study demonstrated the feasibility of DGE placenta MRI at 3.0 Tesla.
Sections du résumé
BACKGROUND
BACKGROUND
To investigate dynamic glucose enhanced (DGE) chemical exchange saturation transfer (CEST) MRI as a means to non-invasively image glucose transport in the human placenta.
METHODS
METHODS
Continuous wave (CW) CEST MRI was performed at 3.0 Tesla. The glucose contrast enhancement (GCE) was calculated based on the magnetization transfer asymmetry (MTRasym), and the DGE was calculated with the positive side of Z-spectra in reference to the first time point. The glucose CEST (GlucoCEST) was optimized using a glucose solution phantom. Glucose solution perfused
RESULTS
RESULTS
The GCE effect peaks at a saturation B1 field of about 2 μT, and the GlucoCEST effect increases linearly with the glucose concentration between 4-20 mM. In
CONCLUSIONS
CONCLUSIONS
Despite the challenges of placental motion and field inhomogeneity, our study demonstrated the feasibility of DGE placenta MRI at 3.0 Tesla.
Identifiants
pubmed: 31728306
doi: 10.21037/qims.2019.09.16
pii: qims-09-10-1619
pmc: PMC6828580
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1619-1627Subventions
Organisme : NICHD NIH HHS
ID : U01 HD087211
Pays : United States
Informations de copyright
2019 Quantitative Imaging in Medicine and Surgery. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: The authors have no conflicts of interest to declare.
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