Subclinical cardiovascular disease in HIV controller and long-term nonprogressor populations.
Adult
Antigens, CD
/ blood
Antigens, Differentiation, Myelomonocytic
/ blood
Biomarkers
/ blood
CD4 Lymphocyte Count
Calcium
/ metabolism
Carotid Artery Diseases
/ blood
Carotid Intima-Media Thickness
Cohort Studies
Female
HIV Infections
/ blood
HIV Long-Term Survivors
/ statistics & numerical data
Humans
Lipopolysaccharide Receptors
/ blood
Male
Middle Aged
Multicenter Studies as Topic
Observational Studies as Topic
Receptors, Cell Surface
/ blood
Tomography, X-Ray Computed
Young Adult
AIDS
HIV
carotid atherosclerosis
coronary atherosclerosis
subclinical cardiovascular disease
Journal
HIV medicine
ISSN: 1468-1293
Titre abrégé: HIV Med
Pays: England
ID NLM: 100897392
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
accepted:
11
10
2019
pubmed:
16
11
2019
medline:
28
9
2021
entrez:
16
11
2019
Statut:
ppublish
Résumé
Elite controllers (ECs), viraemic controllers (VCs), and long-term nonprogressors (LTNPs) control HIV viral replication or maintain CD4 T-cell counts without antiretroviral therapy, but may have increased cardiovascular disease (CVD) risk compared to HIV-uninfected persons. We evaluated subclinical carotid and coronary atherosclerosis and inflammatory biomarker levels among HIV controllers, LTNPs and noncontrollers and HIV-uninfected individuals in the Multicenter AIDS Cohort Study (MACS) and the Women's Interagency HIV Study (WIHS). We measured carotid plaque presence and common carotid artery intima-media thickness (IMT) in 1729 women and 1308 men, and the presence of coronary artery calcium and plaque in a subgroup of men. Associations between HIV control category and carotid and coronary plaque prevalences were assessed by multivariable regression analyses adjusting for demographics and CVD risk factors. Serum inflammatory biomarker concentrations [soluble CD163 (sCD163), soluble CD14 (sCD14), galectin-3 (Gal-3), galectin-3 binding protein (Gal-3BP) and interleukin (IL)-6] were measured and associations with HIV control category assessed. We included 135 HIV controllers (30 ECs) and 135 LTNPs in the study. Carotid plaque prevalence and carotid IMT were similar in HIV controllers, LTNPs and HIV-uninfected individuals. HIV controllers and LTNPs had lower prevalences of carotid plaque compared to viraemic HIV-infected individuals. The prevalence of coronary atherosclerosis was similar in HIV controllers/LTNPs compared to HIV-uninfected and viraemic HIV-infected men. Controllers and LTNPs had higher concentrations of sCD163 and sCD14 compared to HIV-uninfected persons. Subclinical CVD was similar in HIV controllers, LTNPs and HIV-uninfected individuals despite elevated levels of some inflammatory biomarkers. Future studies of HIV controllers and LTNPs are needed to characterize the risk of CVD among HIV-infected persons.
Identifiants
pubmed: 31729142
doi: 10.1111/hiv.12820
pmc: PMC7069771
mid: NIHMS1054831
doi:
Substances chimiques
Antigens, CD
0
Antigens, Differentiation, Myelomonocytic
0
Biomarkers
0
CD14 protein, human
0
CD163 antigen
0
Lipopolysaccharide Receptors
0
Receptors, Cell Surface
0
Calcium
SY7Q814VUP
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
217-227Subventions
Organisme : NIAID NIH HHS
ID : U01 AI103397
Pays : United States
Organisme : National Institute of Allergy and Infectious Diseases
ID : UM1-AI-35043
Pays : International
Organisme : NHLBI NIH HHS
ID : R01 HL095140
Pays : United States
Organisme : National Institute of Allergy and Infectious Diseases
ID : U01-AI-35042
Pays : International
Organisme : NIAID NIH HHS
ID : K24 AI120834
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI035043
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI103401
Pays : United States
Organisme : NHLBI NIH HHS
ID : 5R01 HL095126
Pays : United States
Organisme : National Institute of Allergy and Infectious Diseases
ID : U01-AI-103401
Pays : International
Organisme : NIAID NIH HHS
ID : U01 AI035042
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI140789
Pays : United States
Organisme : Southern California WIHS
ID : U01-HD-032632
Pays : International
Organisme : NCRR NIH HHS
ID : UL1 RR025005
Pays : United States
Organisme : National Institute of Allergy and Infectious Diseases
ID : U01-AI-042590
Pays : International
Organisme : NIAID NIH HHS
ID : U01 AI031834
Pays : United States
Organisme : National Institute of Allergy and Infectious Diseases
ID : U01-AI-103408
Pays : International
Organisme : NCATS NIH HHS
ID : UL1 TR001079
Pays : United States
Organisme : National Institute of Allergy and Infectious Diseases
ID : U01-AI-035004
Pays : International
Organisme : National Institute of Allergy and Infectious Diseases
ID : U01-AI-35041
Pays : International
Organisme : National Institute of Allergy and Infectious Diseases
ID : U01-AI-034989
Pays : International
Organisme : NIAID NIH HHS
ID : U01 AI035004
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL146208
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01-HL-095140
Pays : United States
Organisme : National Institute of Allergy and Infectious Diseases
ID : U01-AI-35039
Pays : International
Organisme : NHLBI NIH HHS
ID : R21 HL120394
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI034989
Pays : United States
Organisme : NHLBI NIH HHS
ID : K01-HL-137557
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000124
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL126543
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL095126
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1-TR000004
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL083760
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132794
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR 025005
Pays : United States
Organisme : National Institute of Allergy and Infectious Diseases
ID : P30-AI-050410
Pays : International
Organisme : NIAID NIH HHS
ID : U01 AI035041
Pays : United States
Organisme : NHLBI NIH HHS
ID : R21-HL-120394
Pays : United States
Organisme : National Institute of Allergy and Infectious Diseases
ID : U01-AI-103397
Pays : International
Organisme : NHLBI NIH HHS
ID : R01 HL095129
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1-TR000124
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI034994
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL146201
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1-TR000454
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG059505
Pays : United States
Organisme : National Institute of Allergy and Infectious Diseases
ID : U01-AI-103390
Pays : International
Organisme : NCATS NIH HHS
ID : UL1 TR000454
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL146193
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01-HL-140976
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL140976
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI027763
Pays : United States
Organisme : National Institute of Allergy and Infectious Diseases
ID : U01-AI-034994
Pays : International
Organisme : NHLBI NIH HHS
ID : U01 HL146204
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL146202
Pays : United States
Organisme : National Institute of Allergy and Infectious Diseases
ID : U01-AI-031834
Pays : International
Organisme : NIAID NIH HHS
ID : U01 AI035040
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI103390
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI034993
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01-HL-126543
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL146240
Pays : United States
Organisme : National Institute of Allergy and Infectious Diseases
ID : U01-AI-35040
Pays : International
Organisme : NCATS NIH HHS
ID : UL1 TR000004
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI035039
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI103408
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01-HL-083760
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01-HL-132794
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1-TR 001079
Pays : United States
Organisme : National Institute of Allergy and Infectious Diseases
ID : U01-AI-034993
Pays : International
Organisme : NIAID NIH HHS
ID : P30 AI050410
Pays : United States
Organisme : NHLBI NIH HHS
ID : K01 HL137557
Pays : United States
Organisme : NICHD NIH HHS
ID : U01 HD032632
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI042590
Pays : United States
Informations de copyright
© 2019 British HIV Association.
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