mTORC1 activity is essential for erythropoiesis and B cell lineage commitment.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
15 11 2019
15 11 2019
Historique:
received:
13
05
2019
accepted:
26
10
2019
entrez:
16
11
2019
pubmed:
16
11
2019
medline:
11
11
2020
Statut:
epublish
Résumé
Mechanistic target of rapamycin (mTOR) is a serine/threonine protein kinase that mediates phosphoinositide-3-kinase (PI3K)/AKT signalling. This pathway is involved in a plethora of cellular functions including protein and lipid synthesis, cell migration, cell proliferation and apoptosis. In this study, we proposed to delineate the role of mTORC1 in haemopoietic lineage commitment using knock out (KO) mouse and cell line models. Mx1-cre and Vav-cre expression systems were used to specifically target Raptor
Identifiants
pubmed: 31729420
doi: 10.1038/s41598-019-53141-1
pii: 10.1038/s41598-019-53141-1
pmc: PMC6858379
doi:
Substances chimiques
Biomarkers
0
Mechanistic Target of Rapamycin Complex 1
EC 2.7.11.1
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
16917Subventions
Organisme : Medical Research Council
ID : MR/K014854/1
Pays : United Kingdom
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