Hypercalcemia Heralding Pneumocystis jirovecii Pneumonia in an HIV-Seronegative Patient with Diffuse Cutaneous Systemic Sclerosis.
Humans
Hypercalcemia
/ physiopathology
Immunocompromised Host
Immunotherapy
/ adverse effects
Male
Middle Aged
Opportunistic Infections
/ diagnosis
Pneumocystis carinii
/ drug effects
Pneumonia, Pneumocystis
/ diagnosis
Scleroderma, Diffuse
/ complications
Trimethoprim, Sulfamethoxazole Drug Combination
/ administration & dosage
Hypercalcemia
Immunocompromised
Pneumocystis pneumonia
Systemic sclerosis
Journal
Mycopathologia
ISSN: 1573-0832
Titre abrégé: Mycopathologia
Pays: Netherlands
ID NLM: 7505689
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
06
01
2019
accepted:
09
10
2019
pubmed:
16
11
2019
medline:
23
4
2020
entrez:
16
11
2019
Statut:
ppublish
Résumé
Pneumocystis pneumonia (PCP) is a life-threatening fungal infection occurring in immunocompromised patients such as HIV-positive patients with low CD4 cell count or patients under heavy immunosuppressive therapy. We report the case of a 59-year-old male with severe diffuse cutaneous systemic sclerosis presenting with asthenia, dry cough and worsening shortness of breath for the last 15 days. Biological studies were remarkable for PTH-independent severe hypercalcemia with low 25-hydroxyvitamin D and a paradoxically elevated 1,25-dihydroxyvitamin D. Early bronchoalveolar lavage allowed for PCP diagnosis and targeted treatment. We discuss the underlying physiopathology and difficulties regarding prophylaxis and treatment.
Identifiants
pubmed: 31729682
doi: 10.1007/s11046-019-00397-w
pii: 10.1007/s11046-019-00397-w
doi:
Substances chimiques
Trimethoprim, Sulfamethoxazole Drug Combination
8064-90-2
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
787-793Références
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