Microdosimetric characterization of clinical carbon-ion beams using synthetic diamond detectors and spectral conversion methods.
carbon beam therapy
microdosimetric spectra conversion
microdosimetry
radiation quality
synthetic-diamond detectors
Journal
Medical physics
ISSN: 2473-4209
Titre abrégé: Med Phys
Pays: United States
ID NLM: 0425746
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
01
08
2019
revised:
17
10
2019
accepted:
09
11
2019
pubmed:
16
11
2019
medline:
24
11
2020
entrez:
16
11
2019
Statut:
ppublish
Résumé
To investigate for the first time the potentialities of obtaining microdosimetric measurements in scanned clinical carbon-ion beams using synthetic single crystal diamond detector and to verify the spectral conversion methods. Microdosimetric measurements were performed at different depths in a water phantom at the therapeutic scanned carbon-ion beam of the National Center of Oncological Hadrontherapy (CNAO) in Pavia, using waterproof encapsulated diamond microdosimeter developed at "Tor Vergata" University. A monoenergetic carbon-ion beam of 195 MeV/μ scanned over a square field of 2 × 2 cm The microdosimetric spectra acquired by the diamond microdosimeter show different shapes in the 10 keV µm Microdosimetric characterization of a synthetic single crystal diamond detector in high-energy scanned carbon-ion beams was performed. The results of the present study showed that this detector is suitable for microdosimetry of clinical carbon ion beams. In addition, the good agreement between the converted diamond spectra and those obtained with TEPC provides the first experimental validation of the spectra conversion methodologies as valuable tools for the comparison of spectra collected with different detectors.
Substances chimiques
Ions
0
Water
059QF0KO0R
Diamond
7782-40-3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
713-721Informations de copyright
© 2019 American Association of Physicists in Medicine.
Références
Schardt D, Elsässer T, Schulz-Ertner D. Heavy-ion tumor therapy: physical and radiobiological benefits. Rev Mod Phys. 2010;82:383-425.
Braccini S. Scientific and technological development of hadrontherapy, e-print arXiv:1001.0860; 2010.
Ma CM, Lomax T. Proton and Carbon Ion Therapy. Boca Raton, FL: CRC; 2013.
Amaldi U, Bonomi R, Braccini S, et al. Accelerators for hadrontherapy: from Lawrence cyclotrons to linacs. Nucl Instrum Methods Phys Res Sec A. 2010;620:563-577.
Wilson RR. Radiological use of fast protons. Radiobiology. 1946;47:487-491.
Loeffler JS, Durante M. Charged particle therapy-optimization, challenges and future directions. Nat Rev Clin Oncol. 2013;10:411-424.
Kraft G. Tumor therapy with heavy charged particles Prog. Part Nucl Phys. 2000;45:S473-S544.
Karger CP, Jäkel O, Palmans H, Kanai T. Dosimetry for ion beam radiotherapy. Phys Med Biol. 2010;55:R193-R234.
De Nardo L, Cesari V, Iborra N, et al. Microdosimetric assessment of nice therapeutic proton beam biological quality Microdosimetric assessment of nice therapeutic proton beam biological quality. Phys Medica. 2004;2:71-77.
Kliauga PJ, Colvett RD, Lam Y-MP, Rossi HH. The relative biological effectiveness of 160 MeV protons I. Microdosimetry. Int J Radiat Oncol Biol Phys. 1978;4:1001-1008.
Kliauga PJ. measurement of single event energy deposition spectra at 5 nm to 250 nm simulated site sizes. Radiat Prot Dosimetry. 1990;31:119-123.
Tran LT, David Bolst S, Guatelli G, et al. High spatial resolution microdosimetry with monolithic Delta E-E detector on C-12 beam: Monte Carlo simulations and experiment. Nucl Instrum Methods Phys Res. 2018;887:70-80.
Wroe A, Schulte R, Fazzi A, Pola A, Agosteo S, Rosenfeld A. RBE estimation of proton radiation fields using a Delta E-E telescope. Med Phys. 2009;36:4486.
Marinelli M, Prestopino G, Verona C, et al. Dosimetric characterization of a microDiamond detector in clinical scanned carbon ion beams. Med Phys. 2015;42:2085-2093.
Mandapaka AK, Ghebremedhin A, Patyal B. et al. The diamond detector was operated at zero bias voltage at all times. Med. Phys. 2013;40:121702.
Rossomme S, Marinelli M, Verona-Rinati G, et al. Response of synthetic diamond detectors in proton, carbon, and oxygen ion beams. Med. Phys. 2017;44:5445-5449.
Davis JA, Davis A, Jeremy P, et al. Tissue equivalence of diamond for heavy charged particles. Radiat Meas. 2019;122:1-9.
Rollet S, Angelone M, Magrin G, et al. A novel microdosimeter based upon artificial single crystal diamond. IEEE Trans Nucl Sci. 2012;59.
Verona C, Magrin G, Solevi P, et al. Spectroscopic properties and radiation damage investigation of a diamond based Schottky diode for ion-beam therapy microdosimetry. J. Appl. Phys. 2015;118:184503.
Verona C, Magrin G, Solevi P, et al. Toward the use of single crystal diamond based detector for ion-beam therapy microdosimetry. Radiat Meas. 2018;110:25-31.
Davis JA, Ganesan K, Alves ADC, et al. Characterization of a Novel diamond-based microdosimeter prototype for radioprotection applications in space environments. IEEE Trans Nucl Sci. 2012;59:3110-3116.
Davis JA, Ganesan K, Prokopovich DA, et al. A 3D lateral electrode structure for diamond based microdosimetry. Appl Phys Lett. 2017;110:013503.
Zahradnik IA, Pomorski MT, De Marzi L, et al. scCVD diamond membrane based microdosimeter for hadron therapy. Phys Status Solidi A. 2018;215:1800383.
Magrin G. A method to convert spectra from slab microdosimeters in therapeutic ion-beams to the spectra referring to microdosimeters of different shapes and material. Phys. Med. Biol. 2018;63:215021.
Magrin G, Verona C, Verona-Rinati G, Stock M. Microdosimetry of clinical ion beams: converting spectra from diamond slab to water of different shapes. Radiat Prot Dosimetry. 2019;183:67-171.
Rossi S. The status of CNAO. Eur Phys J Plus. 2011;126:78.
Rossi S. The national centre for oncological hadrontherapy (CNAO): status and perspectives. Phys Med. 2015;31:333-351.
Mirandola A, Molinelli S, Vilches Freixas G, et al. Dosimetric commissioning and quality assurance of scanned ion beams at the Italian national center for oncological hadrontherapy. Med Phys. 2015;42:5287-5300.
Moro D, Chiriotti S, Conte V, Colautti P, Grosswendt B. Lineal energy calibration of a spherical TEPC. Radiat Prot Dosimetry. 2015;166:233-237.
International Commission on Radiation Units and Measurements.Stopping of Ions Heavier than Helium, ICRU Report 73, Oxford University Press; 2005.
International Commission on Radiation Units and Measurements.Microdosimetry, ICRU Report 36. International Commission on Radiation Units and Measurements. Maryland: Bethesda; 1980.
Lindborg L, Waker A. Microdosimetry, Experimental Methods and Applications. Boca Raton: CRC Press, ISBN 978-1-4822-1740-7; 2017.
Bolst D, Guatelli S, Tran LT. et al. Correction factors to convert microdosimetry measurements in silicon to tissue in 12C ion therapy. Phys Med Biol. 2017;62:2055-2069.
Conte V, Colautti P, Chiriotti S, Moro D,Ciocca M, Mairani A. EPJ Web of Conferences. 2017;153:01012.
Colautti P, Conte V, Selva A, et al. Microdosimetric study at the CNAO active-scanning carbon-ion beam. Radiat Prot Dosimetry. 2018;180:157-161.
IAEA (International Atomic Energy Agency). Absorbed Dose Determination in External Beam Radiotherapy: An International Code of Practice for Dosimetry based on Standards of Absorbed Dose to Water, Technical Report Series No. 398. IAEA, Vienna; 2006.
B. Rosenfled A, Bradley PD, Cornelius I, et al. Solid state microdosimetry in hadron therapy. Radiat Prot Dosim. 2002;101:431-434.