Three new prenyloxy chromanones from aerial parts of Hypericum aucheri.
Antineoplastic Agents, Phytogenic
/ isolation & purification
Apoptosis
Bulgaria
Caspase 9
/ metabolism
Cell Line, Tumor
Chromones
/ isolation & purification
Humans
Hypericum
/ chemistry
Molecular Structure
Phloroglucinol
/ isolation & purification
Phytochemicals
/ isolation & purification
Plant Components, Aerial
/ chemistry
Prenylation
bcl-X Protein
/ metabolism
Aucherines
Bcl-xL
Chromanones
Cytotoxicity
Hypericum aucheri
Procaspase-9
Journal
Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
28
09
2019
revised:
10
11
2019
accepted:
11
11
2019
pubmed:
16
11
2019
medline:
24
12
2019
entrez:
16
11
2019
Statut:
ppublish
Résumé
Three new prenyloxy chromanone derivatives, aucherine A-C (6, 7 and 9) as well as six known prenylated phloroglucinols (1-5 and 8) were isolated from the aerial parts of Hypericum aucheri Jaub. Et Spach. The structures of the isolated compounds were established by means of spectral techniques (HRESIMS, 1D and 2D NMR). The new compounds were tested on а panel of human tumor cell line using MTT assay. All tested compounds exerted moderate cytotoxicity with IC
Identifiants
pubmed: 31730794
pii: S0367-326X(19)31954-9
doi: 10.1016/j.fitote.2019.104421
pii:
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
BCL2L1 protein, human
0
Chromones
0
Phytochemicals
0
bcl-X Protein
0
Phloroglucinol
DHD7FFG6YS
CASP9 protein, human
EC 3.4.22.-
Caspase 9
EC 3.4.22.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104421Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.