Activated protein C assays: A review.

Humans Protein C / analogs & derivatives
Activated protein C ELISA Enzyme capture assay Protein C Protein C inhibitor Venous thrombosis

Journal

Clinica chimica acta; international journal of clinical chemistry
ISSN: 1873-3492
Titre abrégé: Clin Chim Acta
Pays: Netherlands
ID NLM: 1302422

Informations de publication

Date de publication:
Mar 2020
Historique:
received: 16 09 2019
revised: 31 10 2019
accepted: 04 11 2019
pubmed: 16 11 2019
medline: 2 10 2020
entrez: 16 11 2019
Statut: ppublish

Résumé

Activated protein C (APC) acts as an "on demand" anticoagulant, reducing thrombin formation. Reduced plasma levels of APC or protein C (PC) are associated with an increased risk of venous thromboembolism. APC also displays cytoprotective functions and its therapeutic use has been evaluated in severe sepsis and is under evaluation in several diseases with an important inflammatory component. In addition, different studies have revealed a potential role of PC/APC in disorders such as obesity, pneumonia, disseminated intravascular coagulation, Alzheimer, stroke, etc. Accordingly, the therapeutic value of different recombinant APC molecules that lack anticoagulant activity but retain the cytoprotective function is being tested in clinical trials for some of these diseases. Therefore, an available method to measure circulating APC in plasma is of great interests. About 16 different methods for the quantification of APC have been reported. Here, we will review the available assays, highlighting their advantages and disadvantages as well as their different stages of implementation and the most appropriate use for each method, including their potential clinical usefulness.

Identifiants

DOI: 10.1016/j.cca.2019.11.005 PMID: 31730817
pubmed: 31730817
pii: S0009-8981(19)32117-5
doi: 10.1016/j.cca.2019.11.005
pii:
doi:

Substances chimiques

Protein C 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

227-232

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare no conflict of interest.

Auteurs

Julia Oto (J)

Haemostasis, Thrombosis, Atherosclerosis and Vascular Biology Research Group, Medical Research Institute Hospital La Fe (IIS La Fe), Valencia, Spain.

Álvaro Fernández-Pardo (Á)

Haemostasis, Thrombosis, Atherosclerosis and Vascular Biology Research Group, Medical Research Institute Hospital La Fe (IIS La Fe), Valencia, Spain.

Manuel Miralles (M)

Haemostasis, Thrombosis, Atherosclerosis and Vascular Biology Research Group, Medical Research Institute Hospital La Fe (IIS La Fe), Valencia, Spain; Angiology and Vascular Surgery Service, La Fe University and Polytechnic Hospital, Valencia, Spain. Electronic address: miralles_manher@gva.es.

Emma Plana (E)

Haemostasis, Thrombosis, Atherosclerosis and Vascular Biology Research Group, Medical Research Institute Hospital La Fe (IIS La Fe), Valencia, Spain; Angiology and Vascular Surgery Service, La Fe University and Polytechnic Hospital, Valencia, Spain. Electronic address: plana_emm@gva.es.

Francisco España (F)

Haemostasis, Thrombosis, Atherosclerosis and Vascular Biology Research Group, Medical Research Institute Hospital La Fe (IIS La Fe), Valencia, Spain. Electronic address: espanya_fra@gva.es.

Silvia Navarro (S)

Haemostasis, Thrombosis, Atherosclerosis and Vascular Biology Research Group, Medical Research Institute Hospital La Fe (IIS La Fe), Valencia, Spain. Electronic address: navarro_silros@gva.es.

Pilar Medina (P)

Haemostasis, Thrombosis, Atherosclerosis and Vascular Biology Research Group, Medical Research Institute Hospital La Fe (IIS La Fe), Valencia, Spain. Electronic address: medina_pil@gva.es.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Activated protein C assays: A review.
questionsmedicales.fr › Facteurs biologiques › Inhibiteurs des facteurs de la coagulation sanguine › Protéine C › Activated protein C assays: A review.