Hepatic microRNA Expression by PGC-1α and PGC-1β in the Mouse.
PGC-1
coactivators
liver diseases
liver metabolism
microRNA
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 Nov 2019
15 Nov 2019
Historique:
received:
24
10
2019
revised:
12
11
2019
accepted:
13
11
2019
entrez:
17
11
2019
pubmed:
17
11
2019
medline:
9
4
2020
Statut:
epublish
Résumé
The fine-tuning of liver metabolism is essential to maintain the whole-body homeostasis and to prevent the onset of diseases. The peroxisome proliferator-activated receptor-γ coactivators (PGC-1s) are transcriptional key players of liver metabolism, able to regulate mitochondrial function, gluconeogenesis and lipid metabolism. Their activity is accurately modulated by post-translational modifications. Here, we showed that specific PGC-1s expression can lead to the upregulation of different microRNAs widely implicated in liver physiology and diseases development and progression, thus offering a new layer of complexity in the control of hepatic metabolism.
Identifiants
pubmed: 31731670
pii: ijms20225735
doi: 10.3390/ijms20225735
pmc: PMC6888418
pii:
doi:
Substances chimiques
MicroRNAs
0
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
0
Ppargc1a protein, mouse
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : IG 18987
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : PRIN2017J3E2W2_002
Organisme : Joint Programming Initiative A healthy diet for a healthy life
ID : JPI-EU FATMAL
Organisme : Interreg
ID : Interreg V-A Greece-Italy 2014-2020 MIS 500362
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