The Envelope Residues E152/156/158 of Zika Virus Influence the Early Stages of Virus Infection in Human Cells.
Zika virus
cell entry
envelope protein
flavivirus
fusion loop
glycosylation
viral fusion
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
15 11 2019
15 11 2019
Historique:
received:
06
09
2019
revised:
07
11
2019
accepted:
13
11
2019
entrez:
17
11
2019
pubmed:
17
11
2019
medline:
23
7
2020
Statut:
epublish
Résumé
Emerging infections of mosquito-borne Zika virus (ZIKV) pose an increasing threat to human health, as documented over the recent years in South Pacific islands and the Americas in recent years. To better understand molecular mechanisms underlying the increase in human cases with severe pathologies, we recently demonstrated the functional roles of structural proteins capsid (C), pre-membrane (prM), and envelop (E) of ZIKV epidemic strains with the initiation of viral infection in human cells. Specifically, we found that the C-prM region contributes to permissiveness of human host cells to ZIKV infection and ZIKV-induced cytopathic effects, whereas the E protein is associated with viral attachment and early infection. In the present study, we further characterize ZIKV E proteins by investigating the roles of residues isoleucine 152 (Ile152), threonine 156 (Thr156), and histidine 158 (His158) (i.e., the E-152/156/158 residues), which surround a unique
Identifiants
pubmed: 31731738
pii: cells8111444
doi: 10.3390/cells8111444
pmc: PMC6912530
pii:
doi:
Substances chimiques
Viral Envelope Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R21 AI129369
Pays : United States
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