Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge.

Animals Biomarkers Cell Count Disease Susceptibility / immunology ErbB Receptors / metabolism Gene Expression Profiling Gene Expression Regulation Gene Regulatory Networks Ischemia / etiology Macrophages / immunology Macrophages, Alveolar / immunology Mice Muscle Cells / immunology Myocardial Infarction / etiology Organ Specificity / genetics Pneumonia / etiology
macrophage myocardial infarction sepsis stroke

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
19 11 2019
Historique:
received: 01 10 2018
revised: 06 09 2019
accepted: 23 10 2019
pubmed: 17 11 2019
medline: 23 1 2020
entrez: 17 11 2019
Statut: ppublish

Résumé

Myocardial infarction, stroke, and sepsis trigger systemic inflammation and organism-wide complications that are difficult to manage. Here, we examined the contribution of macrophages residing in vital organs to the systemic response after these injuries. We generated a comprehensive catalog of changes in macrophage number, origin, and gene expression in the heart, brain, liver, kidney, and lung of mice with myocardial infarction, stroke, or sepsis. Predominantly fueled by heightened local proliferation, tissue macrophage numbers increased systemically. Macrophages in the same organ responded similarly to different injuries by altering expression of tissue-specific gene sets. Preceding myocardial infarction improved survival of subsequent pneumonia due to enhanced bacterial clearance, which was caused by IFNɣ priming of alveolar macrophages. Conversely, EGF receptor signaling in macrophages exacerbated inflammatory lung injury. Our data suggest that local injury activates macrophages in remote organs and that targeting macrophages could improve resilience against systemic complications following myocardial infarction, stroke, and sepsis.

Identifiants

DOI: 10.1016/j.immuni.2019.10.010 PMID: 31732166 PMC: PMC6892583
pubmed: 31732166
pii: S1074-7613(19)30454-6
doi: 10.1016/j.immuni.2019.10.010
pmc: PMC6892583
mid: NIHMS1543682
pii:
doi:

Substances chimiques

Biomarkers 0
EGFR protein, mouse EC 2.7.10.1
ErbB Receptors EC 2.7.10.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

899-914.e7

Subventions

Organisme : NIAMS NIH HHS
ID : DP2 AR075321
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL125428
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK043351
Pays : United States
Organisme : NHLBI NIH HHS
ID : K99 HL129168
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM083016
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS084863
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK057521
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM053522
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL139598
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM119197
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL076136
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128264
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001442
Pays : United States
Organisme : NCI NIH HHS
ID : R37 CA225655
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL142494
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL129168
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

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Auteurs

Friedrich Felix Hoyer (FF)

Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA.

Kamila Naxerova (K)

Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA.

Maximilian J Schloss (MJ)

Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA.

Maarten Hulsmans (M)

Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA.

Anil V Nair (AV)

Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA; Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Partha Dutta (P)

Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, BST 1720.1, 200 Lothrop Street, Pittsburgh, PA 15213, USA.

David M Calcagno (DM)

Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.

Fanny Herisson (F)

Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA.

Atsushi Anzai (A)

Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA.

Yuan Sun (Y)

Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA.

Gregory Wojtkiewicz (G)

Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA.

David Rohde (D)

Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA.

Vanessa Frodermann (V)

Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA.

Katrien Vandoorne (K)

Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA.

Gabriel Courties (G)

Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA.

Yoshiko Iwamoto (Y)

Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA.

Christopher S Garris (CS)

Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA.

David L Williams (DL)

Department of Surgery and Center of Excellence in Inflammation, Infectious Disease and Immunity, East Tennessee State University, 178 Maple Avenue, Johnson City, TN 37614, USA.

Sylvie Breton (S)

Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA; Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Dennis Brown (D)

Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA; Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Michael Whalen (M)

Neuroscience Center and Department of Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, 55 Fruit Street, MA 02114, USA.

Peter Libby (P)

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

Mikael J Pittet (MJ)

Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA.

Kevin R King (KR)

Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA; Division of Cardiology, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.

Ralph Weissleder (R)

Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA; Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.

Filip K Swirski (FK)

Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA.

Matthias Nahrendorf (M)

Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA; Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA; Department of Internal Medicine I, University Hospital Wuerzburg, Wuerzburg, Germany. Electronic address: mnahrendorf@mgh.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Tissue-Specific Macrophage Responses to Remote...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Tissue-Specific Macrophage Responses to Remote...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Numération cellulaire › Tissue-Specific Macrophage Responses to Remote...
questionsmedicales.fr › Phénomènes physiologiques › Constitution physique › Prédisposition aux maladies › Tissue-Specific Macrophage Responses to Remote...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs ErbB › Tissue-Specific Macrophage Responses to Remote...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Tissue-Specific Macrophage Responses to Remote...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Tissue-Specific Macrophage Responses to Remote...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Séquences d'acides nucléiques régulatrices › Réseaux de régulation génique › Tissue-Specific Macrophage Responses to Remote...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Ischémie › Tissue-Specific Macrophage Responses to Remote...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Tissue-Specific Macrophage Responses to Remote...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Macrophages alvéolaires › Tissue-Specific Macrophage Responses to Remote...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Tissue-Specific Macrophage Responses to Remote...
questionsmedicales.fr › Cellules › Cellules musculaires › Tissue-Specific Macrophage Responses to Remote...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Infarctus › Infarctus du myocarde › Tissue-Specific Macrophage Responses to Remote...
questionsmedicales.fr › Phénomènes physiologiques › Spécificité d'organe › Tissue-Specific Macrophage Responses to Remote...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Tissue-Specific Macrophage Responses to Remote...