Liver Is a Generative Site for the B Cell Response to Ehrlichia muris.

Animals B-Lymphocytes / immunology B7-1 Antigen / biosynthesis Ehrlichia / immunology Ehrlichiosis / immunology Immunoglobulin M / immunology Immunoglobulin Variable Region / genetics Immunologic Memory / immunology Liver / cytology Mice Mice, Inbred C57BL Programmed Cell Death 1 Ligand 2 Protein / biosynthesis Somatic Hypermutation, Immunoglobulin / genetics Spleen / cytology T-Box Domain Proteins / metabolism
Ehrlichia muris T-bet age-associated B cells liver memory B cells plasmablasts somatic hypermutation

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
17 12 2019
Historique:
received: 27 01 2019
revised: 24 07 2019
accepted: 15 10 2019
pubmed: 17 11 2019
medline: 31 1 2020
entrez: 17 11 2019
Statut: ppublish

Résumé

The B cell response to Ehrlichia muris is dominated by plasmablasts (PBs), with few-if any-germinal centers (GCs), yet it generates protective immunoglobulin M (IgM) memory B cells (MBCs) that express the transcription factor T-bet and harbor V-region mutations. Because Ehrlichia prominently infects the liver, we investigated the nature of liver B cell response and that of the spleen. B cells within infected livers proliferated and underwent somatic hypermutation (SHM). Vh-region sequencing revealed trafficking of clones between the spleen and liver and often subsequent local clonal expansion and intraparenchymal localization of T-bet

Identifiants

DOI: 10.1016/j.immuni.2019.10.004 PMID: 31732168 PMC: PMC6955021
pubmed: 31732168
pii: S1074-7613(19)30448-0
doi: 10.1016/j.immuni.2019.10.004
pmc: PMC6955021
mid: NIHMS1543508
pii:
doi:

Substances chimiques

B7-1 Antigen 0
Immunoglobulin M 0
Immunoglobulin Variable Region 0
Pdcd1lg2 protein, mouse 0
Programmed Cell Death 1 Ligand 2 Protein 0
T-Box Domain Proteins 0
T-box transcription factor TBX21 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1088-1101.e5

Subventions

Organisme : NIAID NIH HHS
ID : P01 AI106697
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI043603
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI105018
Pays : United States
Organisme : NIH HHS
ID : S10 OD011925
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

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Auteurs

Nikita Trivedi (N)

Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA; Graduate Program in Microbiology and Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Florian Weisel (F)

Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Shuchi Smita (S)

Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Stephen Joachim (S)

Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Muhamuda Kader (M)

Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Aditya Radhakrishnan (A)

Juno Therapeutics, Seattle, WA 98109, USA.

Chris Clouser (C)

Juno Therapeutics, Seattle, WA 98109, USA.

Aaron M Rosenfeld (AM)

Drexel University, Philadelphia, PA 19104, USA.

Maria Chikina (M)

Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Francois Vigneault (F)

Juno Therapeutics, Seattle, WA 98109, USA.

Uri Hershberg (U)

Drexel University, Philadelphia, PA 19104, USA.

Nahed Ismail (N)

Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Mark Jay Shlomchik (MJ)

Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA. Electronic address: mshlomch@pitt.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Liver Is a Generative Site for the B Cell...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › Liver Is a Generative Site for the B Cell...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Antigènes B7 › Antigène CD80 › Liver Is a Generative Site for the B Cell...
questionsmedicales.fr › Bactéries › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Ehrlichia › Liver Is a Generative Site for the B Cell...
questionsmedicales.fr › Infection › Maladies vectorielles › Maladies transmises par les tiques › Ehrlichiose › Liver Is a Generative Site for the B Cell...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline M › Liver Is a Generative Site for the B Cell...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Région variable d'immunoglobuline › Liver Is a Generative Site for the B Cell...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Mémoire immunologique › Liver Is a Generative Site for the B Cell...
questionsmedicales.fr › Système digestif › Foie › Liver Is a Generative Site for the B Cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Liver Is a Generative Site for the B Cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Liver Is a Generative Site for the B Cell...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Antigènes B7 › Ligand-2 de la protéine-1 de mort cellulaire programmée › Liver Is a Generative Site for the B Cell...
questionsmedicales.fr › Phénomènes du système immunitaire › Phénomènes immunogénétiques › Hypermutation somatique des gènes des immunoglobulines › Liver Is a Generative Site for the B Cell...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Rate › Liver Is a Generative Site for the B Cell...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines à domaine boîte-T › Liver Is a Generative Site for the B Cell...