Structural attributes influencing unbound tissue distribution.

Animals Dose-Response Relationship, Drug Infusions, Intravenous Male Models, Molecular Molecular Structure Organic Chemicals / administration & dosage Pharmaceutical Preparations / administration & dosage Rats Rats, Wistar Structure-Activity Relationship Tissue Distribution
Brain Disposition Drug design Fraction unbound Heart K(puu) Liver Metabolism Pharmacokinetics Skeletal muscle Tissue unbound partition coefficient Transporters White adipose

Journal

European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510

Informations de publication

Date de publication:
01 Jan 2020
Historique:
received: 23 04 2019
revised: 03 09 2019
accepted: 23 10 2019
pubmed: 17 11 2019
medline: 19 2 2020
entrez: 17 11 2019
Statut: ppublish

Résumé

Unbound tissue-to-plasma partition coefficients (K

Identifiants

DOI: 10.1016/j.ejmech.2019.111813 PMID: 31732255
pubmed: 31732255
pii: S0223-5234(19)30965-1
doi: 10.1016/j.ejmech.2019.111813
pii:
doi:

Substances chimiques

Organic Chemicals 0
Pharmaceutical Preparations 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

111813

Informations de copyright

Copyright © 2019 Elsevier Masson SAS. All rights reserved.

Auteurs

Christine C Orozco (CC)

Medicine Design, Pfizer Worldwide Research & Development, Groton, CT, USA.

Karen Atkinson (K)

Medicine Design, Pfizer Worldwide Research & Development, Groton, CT, USA.

Sangwoo Ryu (S)

Medicine Design, Pfizer Worldwide Research & Development, Groton, CT, USA.

George Chang (G)

Medicine Design, Pfizer Worldwide Research & Development, Groton, CT, USA.

Christopher Keefer (C)

Medicine Design, Pfizer Worldwide Research & Development, Groton, CT, USA.

Jian Lin (J)

Medicine Design, Pfizer Worldwide Research & Development, Groton, CT, USA.

Keith Riccardi (K)

Medicine Design, Pfizer Worldwide Research & Development, Groton, CT, USA.

Robert K Mongillo (RK)

Medicine Design, Pfizer Worldwide Research & Development, Groton, CT, USA.

David Tess (D)

Medicine Design, Pfizer Worldwide Research & Development, Cambridge, MA, USA.

Kevin J Filipski (KJ)

Medicine Design, Pfizer Worldwide Research & Development, Cambridge, MA, USA.

Amit S Kalgutkar (AS)

Medicine Design, Pfizer Worldwide Research & Development, Cambridge, MA, USA.

John Litchfield (J)

Medicine Design, Pfizer Worldwide Research & Development, Cambridge, MA, USA.

Dennis Scott (D)

Medicine Design, Pfizer Worldwide Research & Development, Groton, CT, USA.

Li Di (L)

Medicine Design, Pfizer Worldwide Research & Development, Groton, CT, USA. Electronic address: li.di@pfizer.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Structural attributes influencing unbound...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Structural attributes influencing unbound...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Perfusions parentérales › Perfusions veineuses › Structural attributes influencing unbound...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Structural attributes influencing unbound...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Structural attributes influencing unbound...
questionsmedicales.fr › Composés chimiques organiques › Structural attributes influencing unbound...
questionsmedicales.fr › Préparations pharmaceutiques › Structural attributes influencing unbound...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Structural attributes influencing unbound...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Wistar › Structural attributes influencing unbound...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Structural attributes influencing unbound...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Distribution tissulaire › Structural attributes influencing unbound...