A Distinct Class of Bursting Neurons with Strong Gamma Synchronization and Stimulus Selectivity in Monkey V1.
V1
bursting
cell class
cell type
excitatory
gamma
interneuron
orientation tuning
oscillation
synchronization
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
08 01 2020
08 01 2020
Historique:
received:
01
04
2019
revised:
12
07
2019
accepted:
23
09
2019
pubmed:
17
11
2019
medline:
31
3
2020
entrez:
17
11
2019
Statut:
ppublish
Résumé
Cortical computation depends on interactions between excitatory and inhibitory neurons. The contributions of distinct neuron types to sensory processing and network synchronization in primate visual cortex remain largely undetermined. We show that in awake monkey V1, there exists a distinct cell type (››30% of neurons) that has narrow-waveform (NW) action potentials and high spontaneous discharge rates and fires in high-frequency bursts. These neurons are more stimulus selective and phase locked to 30- to 80-Hz gamma oscillations than other neuron types. Unlike other neuron types, their gamma-phase locking is highly predictive of orientation tuning. We find evidence for strong rhythmic inhibition in these neurons, suggesting that they interact with interneurons to act as excitatory pacemakers for the V1 gamma rhythm. We did not find a similar class of NW bursting neurons in L2-L4 of mouse V1. Given its properties, this class of NW bursting neurons should be pivotal for the encoding and transmission of stimulus information.
Identifiants
pubmed: 31732258
pii: S0896-6273(19)30842-6
doi: 10.1016/j.neuron.2019.09.039
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
180-197.e5Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.