Lower midbrain dopamine transporter availability in depressed patients: Report from high-resolution PET imaging.
Adult
Corpus Striatum
/ diagnostic imaging
Depressive Disorder, Major
/ diagnostic imaging
Dopamine Plasma Membrane Transport Proteins
/ metabolism
Female
Humans
Male
Mesencephalon
/ diagnostic imaging
Middle Aged
Molecular Imaging
/ methods
Positron-Emission Tomography
/ methods
Putamen
/ diagnostic imaging
Substantia Nigra
/ diagnostic imaging
DAT
Depression
Neuroimaging
PET
Journal
Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073
Informations de publication
Date de publication:
01 02 2020
01 02 2020
Historique:
received:
24
05
2019
revised:
04
09
2019
accepted:
28
10
2019
pubmed:
17
11
2019
medline:
26
1
2021
entrez:
17
11
2019
Statut:
ppublish
Résumé
A reduced presynaptic dopamine neurotransmission has long been implicated in major depressive disorder (MDD). However, molecular imaging studies that assessed the dopamine transporter (DAT) availability have led to inconsistent results, partly due to methodological considerations, and to exclusive focus on the striatum, precluding findings in extra-striatal regions. Herein, we leveraged our database of high-resolution Positron Emission Tomography (PET) images acquired with a highly selective radiotracer, [ Statistical parametric mapping and voxel-based analyses of PET images detected a significant lower DAT availability in depressed patients within the superior part of the midbrain (right, p The statistical power was limited to detect only large effects, due to the size of the patients' sample. The findings support the hypothesis that a reduced presynaptic dopamine function plays a role in the pathophysiology of depression, and that extra-striatal dopamine function should be further investigated.
Sections du résumé
BACKGROUND
A reduced presynaptic dopamine neurotransmission has long been implicated in major depressive disorder (MDD). However, molecular imaging studies that assessed the dopamine transporter (DAT) availability have led to inconsistent results, partly due to methodological considerations, and to exclusive focus on the striatum, precluding findings in extra-striatal regions.
METHODS
Herein, we leveraged our database of high-resolution Positron Emission Tomography (PET) images acquired with a highly selective radiotracer, [
RESULTS
Statistical parametric mapping and voxel-based analyses of PET images detected a significant lower DAT availability in depressed patients within the superior part of the midbrain (right, p
LIMITATIONS
The statistical power was limited to detect only large effects, due to the size of the patients' sample.
CONCLUSIONS
The findings support the hypothesis that a reduced presynaptic dopamine function plays a role in the pathophysiology of depression, and that extra-striatal dopamine function should be further investigated.
Identifiants
pubmed: 31732277
pii: S0165-0327(19)31371-0
doi: 10.1016/j.jad.2019.10.041
pii:
doi:
Substances chimiques
Dopamine Plasma Membrane Transport Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
273-277Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.