Foam Cells: One Size Doesn't Fit All.
atherosclerosis
chronic inflammation
foam cells
lipid droplets
macrophage
tuberculosis
Journal
Trends in immunology
ISSN: 1471-4981
Titre abrégé: Trends Immunol
Pays: England
ID NLM: 100966032
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
03
06
2019
revised:
10
10
2019
accepted:
12
10
2019
pubmed:
17
11
2019
medline:
24
7
2020
entrez:
17
11
2019
Statut:
ppublish
Résumé
Chronic inflammation in many infectious and metabolic diseases, and some cancers, is accompanied by the presence of foam cells. These cells form when the intracellular lipid content of macrophages exceeds their capacity to maintain lipid homeostasis. Concurrently, critical macrophage immune functions are diminished. Current paradigms of foam cell formation derive from studies of atherosclerosis. However, recent studies indicate that the mechanisms of foam cell biogenesis during tuberculosis differ from those operating during atherogenesis. Here, we review how foam cell formation and function vary with disease context. Since foam cells are therapeutic targets in atherosclerosis, further research on the disease-specific mechanisms of foam cell biogenesis and function is needed to explore the therapeutic consequences of targeting these cells in other diseases.
Identifiants
pubmed: 31732284
pii: S1471-4906(19)30211-X
doi: 10.1016/j.it.2019.10.002
pmc: PMC6925453
mid: NIHMS1544600
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1163-1179Subventions
Organisme : NIAID NIH HHS
ID : R01 AI104615
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL149450
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
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