Biogenic platinum nanoparticles using black cumin seed and their potential usage as antimicrobial and anticancer agent.
Anti-Bacterial Agents
/ administration & dosage
Antineoplastic Agents, Phytogenic
/ administration & dosage
Breast Neoplasms
/ drug therapy
Cell Line, Tumor
Dose-Response Relationship, Drug
Female
Gram-Negative Bacteria
/ drug effects
Gram-Positive Bacteria
/ drug effects
HeLa Cells
Humans
Inhibitory Concentration 50
Metal Nanoparticles
Nigella sativa
/ chemistry
Plant Extracts
/ administration & dosage
Platinum
/ chemistry
Seeds
Uterine Cervical Neoplasms
/ drug therapy
Antibacterial
Anticancer
Biogenic platinum nanoparticles
HeLa cervical cancer lines
MDA-MB-231
Nigella sativa L.
Journal
Journal of pharmaceutical and biomedical analysis
ISSN: 1873-264X
Titre abrégé: J Pharm Biomed Anal
Pays: England
ID NLM: 8309336
Informations de publication
Date de publication:
05 Feb 2020
05 Feb 2020
Historique:
received:
31
08
2019
revised:
15
10
2019
accepted:
28
10
2019
pubmed:
17
11
2019
medline:
13
11
2020
entrez:
17
11
2019
Statut:
ppublish
Résumé
Herein, the biogenic platinum nanoparticles (Pt NPs) were synthesized by using black cumin seed (Nigella sativa L.) extract as a reducing agent. The biogenic platinum nanoparticles synthesized by black cumin seed extract was characterized in detail by Transmission Electron Microscopy (TEM), UV-vis spectrophotometer, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS). According to TEM analysis, Pt nanoparticles have spherical shapes and sizes between 1-6 nm. Moreover, the biogenic Pt NPs was assessed for its cytotoxicity effect on MDA-MB-231 breast and HeLa cervical cancer lines and their antibacterial effect against selected strains of gram-positive and negative bacteria. The cytotoxicity and bacterial tests showed the effectiveness of biogenic Pt nanoparticles. Dose-dependent toxicity effects were shown in the MDA-MB-231 breast and HeLa cervical cancer lines (IC50: 36.86 μg/mL and 19.83 μg/mL, respectively). In addition, Pt NPs showed high zone diameters against gram-positive and gram-negative bacteria at concentrations of 100 and 500 μg/ml. These results contribute to the development of the pharmaceutical industry as a potential antibacterial and anticancer agent.
Identifiants
pubmed: 31732404
pii: S0731-7085(19)32137-5
doi: 10.1016/j.jpba.2019.112961
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antineoplastic Agents, Phytogenic
0
Plant Extracts
0
Platinum
49DFR088MY
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112961Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.