IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection.

Animals Antigens, Bacterial / immunology Interleukin-23 / immunology Legionella / immunology Legionnaires' Disease / immunology Mice Mice, Inbred C57BL Mice, Knockout Mucosal-Associated Invariant T Cells / immunology Vaccination

Journal

Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624

Informations de publication

Date de publication:
15 11 2019
Historique:
received: 20 11 2018
revised: 09 05 2019
accepted: 18 10 2019
entrez: 17 11 2019
pubmed: 17 11 2019
medline: 30 7 2020
Statut: ppublish

Résumé

Mucosal-associated invariant T (MAIT) cells are activated in a TCR-dependent manner by antigens derived from the riboflavin synthesis pathway, including 5-(2-oxopropylideneamino)-6-d-ribitylaminouracil (5-OP-RU), bound to MHC-related protein-1 (MR1). However, MAIT cell activation in vivo has not been studied in detail. Here, we have found and characterized additional molecular signals required for optimal activation and expansion of MAIT cells after pulmonary

Identifiants

DOI: 10.1126/sciimmunol.aaw0402 PMID: 31732518
pubmed: 31732518
pii: 4/41/eaaw0402
doi: 10.1126/sciimmunol.aaw0402
pii:
doi:

Substances chimiques

Antigens, Bacterial 0
Interleukin-23 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Auteurs

Huimeng Wang (H)

Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China.
ORCID: 0000-0003-0226-3982

Lars Kjer-Nielsen (L)

Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
ORCID: 0000-0003-3215-2888

Mai Shi (M)

Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
School of Medicine, Tsinghua University, Beijing, China.
ORCID: 0000-0002-1046-1391

Criselle D'Souza (C)

Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Sir Peter MacCallum Department of Oncology, University of Melbourne, VIC 3010, Australia.
ORCID: 0000-0003-2257-6388

Troi J Pediongco (TJ)

Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.

Hanwei Cao (H)

Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.

Lyudmila Kostenko (L)

Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.

Xin Yi Lim (XY)

Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
ORCID: 0000-0002-9806-5894

Sidonia B G Eckle (SBG)

Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.

Bronwyn S Meehan (BS)

Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
ORCID: 0000-0001-7368-2979

Tianyuan Zhu (T)

Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
School of Medicine, Tsinghua University, Beijing, China.

Bingjie Wang (B)

Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.

Zhe Zhao (Z)

Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
ORCID: 0000-0003-1009-324X

Jeffrey Y W Mak (JYW)

Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Saint Lucia, QLD 4072, Australia.
Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Queensland, Saint Lucia, QLD 4072, Australia.
ORCID: 0000-0002-8011-4539

David P Fairlie (DP)

Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Saint Lucia, QLD 4072, Australia.
Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Queensland, Saint Lucia, QLD 4072, Australia.
ORCID: 0000-0002-7856-8566

Michele W L Teng (MWL)

QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.
ORCID: 0000-0003-1886-9145

Jamie Rossjohn (J)

Infection and Immunity Program and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia.
Institute of Infection and Immunity, Cardiff University, School of Medicine, Heath Park, CF14 4XN Wales, UK.
ORCID: 0000-0002-2020-7522

Di Yu (D)

John Curtin School of Medical Research, The Australian National University, Acton, ACT 2601 Australia.
ORCID: 0000-0003-1721-8922

Barbara Fazekas de St Groth (BF)

Discipline of Pathology, Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia.
ORCID: 0000-0001-6817-9690

George Lovrecz (G)

Biomedical Manufacturing, CSIRO, Parkville, VIC, 3052, Australia.

Louis Lu (L)

Biomedical Manufacturing, CSIRO, Parkville, VIC, 3052, Australia.

James McCluskey (J)

Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
ORCID: 0000-0002-8597-815X

Richard A Strugnell (RA)

Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia. zhenjun@unimelb.edu.au corbetta@unimelb.edu.au rastru@unimelb.edu.au.
ORCID: 0000-0003-0614-5641

Alexandra J Corbett (AJ)

Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia. zhenjun@unimelb.edu.au corbetta@unimelb.edu.au rastru@unimelb.edu.au.
ORCID: 0000-0003-1618-4337

Zhenjun Chen (Z)

Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia. zhenjun@unimelb.edu.au corbetta@unimelb.edu.au rastru@unimelb.edu.au.
ORCID: 0000-0003-1205-683X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › IL-23 costimulates antigen-specific MAIT cell...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes bactériens › IL-23 costimulates antigen-specific MAIT cell...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-23 › IL-23 costimulates antigen-specific MAIT cell...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Legionellaceae › Legionella › IL-23 costimulates antigen-specific MAIT cell...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Légionellose › Maladie des légionnaires › IL-23 costimulates antigen-specific MAIT cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › IL-23 costimulates antigen-specific MAIT cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › IL-23 costimulates antigen-specific MAIT cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › IL-23 costimulates antigen-specific MAIT cell...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Cellules T invariantes associées aux muqueuses › IL-23 costimulates antigen-specific MAIT cell...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pratiques en santé publique › Prévention primaire › Immunisation › Vaccination › IL-23 costimulates antigen-specific MAIT cell...