Grey matter volume in developmental speech and language disorder.


Journal

Brain structure & function
ISSN: 1863-2661
Titre abrégé: Brain Struct Funct
Pays: Germany
ID NLM: 101282001

Informations de publication

Date de publication:
Dec 2019
Historique:
received: 24 05 2019
accepted: 04 11 2019
pubmed: 17 11 2019
medline: 15 4 2020
entrez: 17 11 2019
Statut: ppublish

Résumé

Developmental language disorder (DLD) and developmental speech disorder (DSD) are common, yet their etiologies are not well understood. Atypical volume of the inferior and posterior language regions and striatum have been reported in DLD; however, variability in both methodology and study findings limits interpretations. Imaging research within DSD, on the other hand, is scarce. The present study compared grey matter volume in children with DLD, DSD, and typically developing speech and language. Compared to typically developing controls, children with DLD had larger volume in the right cerebellum, possibly associated with the procedural learning deficits that have been proposed in DLD. Children with DSD showed larger volume in the left inferior occipital lobe compared to controls, which may indicate a compensatory role of the visual processing regions due to sub-optimal auditory-perceptual processes. Overall, these findings suggest that different neural systems may be involved in the specific deficits related to DLD and DSD.

Identifiants

pubmed: 31732792
doi: 10.1007/s00429-019-01978-7
pii: 10.1007/s00429-019-01978-7
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3387-3398

Subventions

Organisme : National Health and Medical Research Council
ID : 607315
Organisme : National Health and Medical Research Council
ID : 1105008
Organisme : National Health and Medical Research Council
ID : 1116976
Organisme : National Health and Medical Research council
ID : 1023493
Organisme : Centre for Research Excellence
ID : 1023493

Auteurs

Lauren Pigdon (L)

Murdoch Children's Research Institute, 50 Flemington Rd, Parkville, VIC, 3052, Australia.
Turner Institute for Brain and Mental Health, Monash University, 18 Innovation Walk, Clayton, VIC, 3800, Australia.

Catherine Willmott (C)

Turner Institute for Brain and Mental Health, Monash University, 18 Innovation Walk, Clayton, VIC, 3800, Australia.
Monash-Epworth Rehabilitation Research Centre, Monash University, 18 Innovation Walk, Clayton, VIC, 3800, Australia.

Sheena Reilly (S)

Murdoch Children's Research Institute, 50 Flemington Rd, Parkville, VIC, 3052, Australia.
Menzies Health Institute Queensland, Griffith University, G40 Level 8.86, Mount Gravatt, QLD, 4222, Australia.

Gina Conti-Ramsden (G)

Murdoch Children's Research Institute, 50 Flemington Rd, Parkville, VIC, 3052, Australia.
The University of Manchester, Oxford Rd, Manchester, M13 9PL, UK.

Christian Gaser (C)

Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany.

Alan Connelly (A)

Florey Institute of Neuroscience and Mental Health, 245 Burgundy Street, Heidelberg, VIC, 3084, Australia.
University of Melbourne, Grattan Street, Parkville, VIC, 3010, Australia.

Angela T Morgan (AT)

Murdoch Children's Research Institute, 50 Flemington Rd, Parkville, VIC, 3052, Australia. angela.morgan@mcri.edu.au.
University of Melbourne, Grattan Street, Parkville, VIC, 3010, Australia. angela.morgan@mcri.edu.au.
Royal Children's Hospital, 50 Flemington Rd, Parkville, VIC, 3052, Australia. angela.morgan@mcri.edu.au.

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Classifications MeSH