Disparate Central and Peripheral Effects of Circulating IGF-1 Deficiency on Tissue Mitochondrial Function.

Aging / metabolism Animals Brain / metabolism Cognition / physiology Cognitive Dysfunction / metabolism Disease Models, Animal Hippocampus / metabolism Insulin-Like Growth Factor I / deficiency Mice, Inbred C57BL Mitochondria / genetics Neurons / metabolism Reactive Oxygen Species / metabolism
Cognitive function IGF-1 Learning and memory Mitochondria Oxidative stress ROS

Journal

Molecular neurobiology
ISSN: 1559-1182
Titre abrégé: Mol Neurobiol
Pays: United States
ID NLM: 8900963

Informations de publication

Date de publication:
Mar 2020
Historique:
received: 02 07 2019
accepted: 23 10 2019
pubmed: 17 11 2019
medline: 15 12 2020
entrez: 17 11 2019
Statut: ppublish

Résumé

Age-related decline in circulating levels of insulin-like growth factor (IGF)-1 is associated with reduced cognitive function, neuronal aging, and neurodegeneration. Decreased mitochondrial function along with increased reactive oxygen species (ROS) and accumulation of damaged macromolecules are hallmarks of cellular aging. Based on numerous studies indicating pleiotropic effects of IGF-1 during aging, we compared the central and peripheral effects of circulating IGF-1 deficiency on tissue mitochondrial function using an inducible liver IGF-1 knockout (LID). Circulating levels of IGF-1 (~ 75%) were depleted in adult male Igf1

Identifiants

DOI: 10.1007/s12035-019-01821-4 PMID: 31732912 PMC: PMC7060968
pubmed: 31732912
doi: 10.1007/s12035-019-01821-4
pii: 10.1007/s12035-019-01821-4
pmc: PMC7060968
doi:

Substances chimiques

Reactive Oxygen Species 0
insulin-like growth factor-1, mouse 0
Insulin-Like Growth Factor I 67763-96-6

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1317-1331

Subventions

Organisme : NIA NIH HHS
ID : K99AG056662
Pays : United States
Organisme : NIA NIH HHS
ID : T32AG052363
Pays : United States
Organisme : NIA NIH HHS
ID : K99 AG056662
Pays : United States
Organisme : NIA NIH HHS
ID : R01AG038747
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103447
Pays : United States
Organisme : NINDS NIH HHS
ID : R01NS056218
Pays : United States
Organisme : NIA NIH HHS
ID : P30AG050911
Pays : United States

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Auteurs

Gavin Pharaoh (G)

Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Oklahoma Center for Geroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Daniel Owen (D)

Oklahoma Center for Geroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Alexander Yeganeh (A)

Oklahoma Center for Geroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Pavithra Premkumar (P)

Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.

Julie Farley (J)

Oklahoma Center for Geroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Shylesh Bhaskaran (S)

Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Oklahoma Center for Geroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Nicole Ashpole (N)

Department of Biomolecular Sciences, University of Mississippi, Oxford, MS, USA.

Michael Kinter (M)

Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Oklahoma Center for Geroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Holly Van Remmen (H)

Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Oklahoma Center for Geroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Sreemathi Logan (S)

Oklahoma Center for Geroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Sreemathi-Logan@ouhsc.edu.
Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Sreemathi-Logan@ouhsc.edu.
Department of Rehabilitation Sciences, College of Allied Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Sreemathi-Logan@ouhsc.edu.
ORCID: 0000-0001-9160-0383

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Disparate Central and Peripheral Effects of...
questionsmedicales.fr › Eucaryotes › Animaux › Disparate Central and Peripheral Effects of...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Disparate Central and Peripheral Effects of...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Disparate Central and Peripheral Effects of...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Disparate Central and Peripheral Effects of...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Disparate Central and Peripheral Effects of...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Disparate Central and Peripheral Effects of...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Somatomédines › Facteur de croissance IGF-I › Disparate Central and Peripheral Effects of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Disparate Central and Peripheral Effects of...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Disparate Central and Peripheral Effects of...
questionsmedicales.fr › Cellules › Neurones › Disparate Central and Peripheral Effects of...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Disparate Central and Peripheral Effects of...