Trefoil Factor Family 1 Inhibits the Development of Hepatocellular Carcinoma by Regulating β-Catenin Activation.
Journal
Hepatology (Baltimore, Md.)
ISSN: 1527-3350
Titre abrégé: Hepatology
Pays: United States
ID NLM: 8302946
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
14
05
2019
accepted:
07
11
2019
pubmed:
17
11
2019
medline:
30
4
2021
entrez:
17
11
2019
Statut:
ppublish
Résumé
Recent studies have suggested that trefoil factor family 1 (TFF1) functions as a tumor suppressor in gastric and pancreatic carcinogenesis. To investigate the role of TFF1 in hepatocarcinogenesis, we performed immunohistochemical staining of surgically resected human liver samples, transfected a TFF1 expression vector into hepatocellular carcinoma (HCC) cell lines, and employed a mouse model of spontaneous HCC development (albumin-cyclization recombination/Lox-Stop-Lox sequence-Kirsten rat sarcoma viral oncogene homolog TFF1 might function as a tumor suppressor that inhibits the development of HCC by regulating β-catenin activity.
Sections du résumé
BACKGROUND AND AIMS
Recent studies have suggested that trefoil factor family 1 (TFF1) functions as a tumor suppressor in gastric and pancreatic carcinogenesis.
APPROACH AND RESULTS
To investigate the role of TFF1 in hepatocarcinogenesis, we performed immunohistochemical staining of surgically resected human liver samples, transfected a TFF1 expression vector into hepatocellular carcinoma (HCC) cell lines, and employed a mouse model of spontaneous HCC development (albumin-cyclization recombination/Lox-Stop-Lox sequence-Kirsten rat sarcoma viral oncogene homolog
CONCLUSIONS
TFF1 might function as a tumor suppressor that inhibits the development of HCC by regulating β-catenin activity.
Substances chimiques
Tff1 protein, mouse
0
Trefoil Factor-1
0
Tumor Suppressor Proteins
0
beta Catenin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
503-517Informations de copyright
© 2019 by the American Association for the Study of Liver Diseases.
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