Companion animal models of neurological disease.
Animal models
Epilepsy
Movement disorders
Neuro-oncology
Neurodegenerative disease
Spinal cord injury
Stroke
Journal
Journal of neuroscience methods
ISSN: 1872-678X
Titre abrégé: J Neurosci Methods
Pays: Netherlands
ID NLM: 7905558
Informations de publication
Date de publication:
01 02 2020
01 02 2020
Historique:
received:
25
08
2019
revised:
28
10
2019
accepted:
28
10
2019
pubmed:
17
11
2019
medline:
22
6
2021
entrez:
17
11
2019
Statut:
ppublish
Résumé
Clinical translation of novel therapeutics that improve the survival and quality of life of patients with neurological disease remains a challenge, with many investigational drug and device candidates failing in advanced stage clinical trials. Naturally occurring inherited and acquired neurological diseases, such as epilepsy, inborn errors of metabolism, brain tumors, spinal cord injury, and stroke occur frequently in companion animals, and many of these share epidemiologic, pathophysiologic and clinical features with their human counterparts. As companion animals have a relatively abbreviated lifespan and genetic background, are immunocompetent, share their environment with human caregivers, and can be clinically managed using techniques and tools similar to those used in humans, they have tremendous potential for increasing the predictive value of preclinical drug and device studies. Here, we review comparative features of spontaneous neurological diseases in companion animals with an emphasis on neuroimaging methods and features, illustrate their historical use in translational studies, and discuss inherent limitations associated with each disease model. Integration of companion animals with naturally occurring disease into preclinical studies can complement and expand the knowledge gained from studies in other animal models, accelerate or improve the manner in which research is translated to the human clinic, and ultimately generate discoveries that will benefit the health of humans and animals.
Identifiants
pubmed: 31733285
pii: S0165-0270(19)30341-3
doi: 10.1016/j.jneumeth.2019.108484
pmc: PMC6942211
mid: NIHMS1544558
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
108484Subventions
Organisme : NCI NIH HHS
ID : P01 CA207206
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA012197
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA139099
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA213423
Pays : United States
Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier B.V. All rights reserved.
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