Ion occupancy of the channel pore is critical for triggering excitation-transcription (ET) coupling.

Calcineurin / metabolism Calcium / chemistry Calcium Channels, L-Type / chemistry Calcium Signaling Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism Calmodulin Excitation Contraction Coupling HEK293 Cells Humans Ions / chemistry Lanthanum / chemistry MAP Kinase Signaling System Membrane Potentials Structure-Activity Relationship Transcriptional Activation
Ca(2+)/calmodulin CaMKII ET-coupling Lanthanum MAPK Timothy channel Transcription

Journal

Cell calcium
ISSN: 1532-1991
Titre abrégé: Cell Calcium
Pays: Netherlands
ID NLM: 8006226

Informations de publication

Date de publication:
Dec 2019
Historique:
received: 10 07 2019
revised: 07 10 2019
accepted: 07 10 2019
pubmed: 17 11 2019
medline: 25 9 2020
entrez: 17 11 2019
Statut: ppublish

Résumé

During membrane depolarization the voltage-gated calcium channel (VGCC) activates gene expression in excitable cells by means of a signal-transduction pathway termed excitation transcription (ET) coupling. The L-type calcium channel Cav1.2 can drive nuclear activity by either the ERK-CREB pathway, the Ca

Identifiants

DOI: 10.1016/j.ceca.2019.102102 PMID: 31733625
pubmed: 31733625
pii: S0143-4160(19)30169-1
doi: 10.1016/j.ceca.2019.102102
pii:
doi:

Substances chimiques

Calcium Channels, L-Type 0
Calmodulin 0
Ions 0
L-type calcium channel alpha(1C) 0
Lanthanum 6I3K30563S
Calcium-Calmodulin-Dependent Protein Kinase Type 2 EC 2.7.11.17
Calcineurin EC 3.1.3.16
Calcium SY7Q814VUP

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

102102

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Evrim Servili (E)

Dept. of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.

Michael Trus (M)

Dept. of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.

Daphne Atlas (D)

Dept. of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel. Electronic address: daphne.atlas@mail.huji.ac.il.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphoprotein Phosphatases › Calcineurine › Ion occupancy of the channel pore is critical...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Ion occupancy of the channel pore is critical...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux calciques › Canaux calciques de type L › Ion occupancy of the channel pore is critical...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Systèmes de seconds messagers › Signalisation calcique › Ion occupancy of the channel pore is critical...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Calcium-Calmodulin-Dependent Protein Kinases › Calcium-Calmodulin-Dependent Protein Kinase Type 2 › Ion occupancy of the channel pore is critical...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines intracellulaires sensibles au calcium › Calmoduline › Ion occupancy of the channel pore is critical...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Contraction musculaire › Couplage excitation-contraction › Ion occupancy of the channel pore is critical...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Ion occupancy of the channel pore is critical...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Ion occupancy of the channel pore is critical...
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Ion occupancy of the channel pore is critical...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Terres rares › Lanthanides › Lanthane › Ion occupancy of the channel pore is critical...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Système de signalisation des MAP kinases › Ion occupancy of the channel pore is critical...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Potentiels de membrane › Ion occupancy of the channel pore is critical...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Ion occupancy of the channel pore is critical...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Activation de la transcription › Ion occupancy of the channel pore is critical...