Orthostatic Hypotension in Parkinson Disease.

Aged Humans Hypotension, Orthostatic / etiology Parkinson Disease / physiopathology Patient Care Management / methods
Autonomic failure Baroreflex dysfunction Droxidopa Midodrine Neurogenic orthostatic hypotension Norepinephrine

Journal

Clinics in geriatric medicine
ISSN: 1879-8853
Titre abrégé: Clin Geriatr Med
Pays: United States
ID NLM: 8603766

Informations de publication

Date de publication:
02 2020
Historique:
entrez: 18 11 2019
pubmed: 18 11 2019
medline: 16 6 2021
Statut: ppublish

Résumé

Orthostatic hypotension (OH) is a sustained fall in blood pressure on standing that can cause symptoms of organ hypoperfusion. OH is associated with increased morbidity and mortality and leads to a significant number of hospital admissions. OH can be caused by volume depletion, blood loss, cardiac pump failure, large varicose veins, medications, or defective activation of sympathetic nerves and reduced norepinephrine release upon standing. Neurogenic OH is a frequent and disabling problem in patients with synucleinopathies such as Parkinson disease, multiple system atrophy, and pure autonomic failure, and it is commonly associated with supine hypertension. Several therapeutic options are available.

Identifiants

DOI: 10.1016/j.cger.2019.09.002 PMID: 31733702 PMC: PMC7029426
pubmed: 31733702
pii: S0749-0690(19)30077-1
doi: 10.1016/j.cger.2019.09.002
pmc: PMC7029426
mid: NIHMS1544458
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

53-67

Subventions

Organisme : NINDS NIH HHS
ID : U54 NS065736
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

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Auteurs

Jose-Alberto Palma (JA)

Department of Neurology, Dysautonomia Center, New York University School of Medicine, NYU Langone Health, 530 First Avenue, Suite 9Q, New York, NY 10016, USA.

Horacio Kaufmann (H)

Department of Neurology, Dysautonomia Center, New York University School of Medicine, NYU Langone Health, 530 First Avenue, Suite 9Q, New York, NY 10016, USA. Electronic address: Horacio.Kaufmann@nyulangone.org.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Orthostatic Hypotension in Parkinson Disease.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Orthostatic Hypotension in Parkinson Disease.
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Hypotension artérielle › Hypotension orthostatique › Orthostatic Hypotension in Parkinson Disease.
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Orthostatic Hypotension in Parkinson Disease.
questionsmedicales.fr › Administration des services de santé › Gestion des soins aux patients › Orthostatic Hypotension in Parkinson Disease.