Cross-Talk Between circRNAs and mRNAs Modulates MiRNA-mediated Circuits and Affects Melanoma Plasticity.
Melanoma
Phenotypic switching
ZEB1
circRNA
Journal
Cancer microenvironment : official journal of the International Cancer Microenvironment Society
ISSN: 1875-2292
Titre abrégé: Cancer Microenviron
Pays: Netherlands
ID NLM: 101322634
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
26
04
2019
accepted:
20
08
2019
pubmed:
18
11
2019
medline:
18
11
2019
entrez:
18
11
2019
Statut:
ppublish
Résumé
CircularRNAs (circRNAs) are non-coding RNAs which compete for microRNA (miRNA) binding, influencing the abundance and stability of other RNA species. Herein we have investigated the effect of circRNAs on the mir200-ZEB1 feedback loop in relationship with the aggressiveness of human melanoma cells. We first compared the level of expression of key factors in the mir200-ZEB1 feedback loop in primary human melanoma cells compared with their matching metastatic one and found a correlation between the aggressiveness of the cells and the level of expression of ZEB1 and SNAI1. We also analyzed factors in the mir200-ZEB1 feedback loop, including circZEB1, during the phenotypic switching of human melanoma cells. Our results showed a correlation between the level of ZEB1 and SNAI1 and the fraction of cancer stem cells in the population. The level of circZEB1 was, however, consistently high during the entire phenotypic transformation. To understand this result we propose a mathematical model of the regulatory circuit. According to the model, the experimental observations can be explained by the presence of a back-splicing factor limiting circRNA production.
Identifiants
pubmed: 31734859
doi: 10.1007/s12307-019-00230-4
pii: 10.1007/s12307-019-00230-4
pmc: PMC6937352
doi:
Types de publication
Journal Article
Langues
eng
Pagination
95-104Subventions
Organisme : AIRC
ID : IG2018-ID 21558
Références
J Theor Biol. 2018 Oct 7;454:386-395
pubmed: 29964064
N Engl J Med. 2016 Sep 22;375(12):1109-12
pubmed: 27653561
Cell Rep. 2015 Jan 6;10(1):103-11
pubmed: 25543144
Int J Cancer. 2015 Dec 1;137(11):2566-77
pubmed: 26077342
Nucleic Acids Res. 2018 Jan 4;46(D1):D754-D761
pubmed: 29155950
J Dermatol Sci. 2016 Sep;83(3):210-8
pubmed: 27298156
Oncogene. 2005 Mar 31;24(14):2375-85
pubmed: 15674322
Br J Cancer. 2014 Mar 18;110(6):1614-21
pubmed: 24504363
RNA Biol. 2015;12(4):381-8
pubmed: 25746834
RNA. 2010 May;16(5):1032-9
pubmed: 20348442
Cancer Cell Int. 2018 Aug 13;18:116
pubmed: 30123094
Semin Cancer Biol. 2017 Jun;44:3-9
pubmed: 28254567
RNA. 2014 Nov;20(11):1666-70
pubmed: 25234927
Nat Rev Mol Cell Biol. 2016 Apr;17(4):205-11
pubmed: 26908011
Front Oncol. 2015 Jul 20;5:155
pubmed: 26258068
Cell Res. 2015 Aug;25(8):981-4
pubmed: 26138677
J Clin Invest. 2009 Jun;119(6):1420-8
pubmed: 19487818
Science. 2013 Feb 1;339(6119):543-8
pubmed: 23239622
Cell. 2010 Apr 2;141(1):69-80
pubmed: 20371346
Sci Rep. 2017 Mar 07;7:43673
pubmed: 28266541
Nat Commun. 2016 Apr 06;7:11215
pubmed: 27050392
Cancer Res. 2013 Sep 15;73(18):5609-12
pubmed: 24014594
Wiley Interdiscip Rev RNA. 2012 Jul-Aug;3(4):593-600
pubmed: 22461385
Trends Biochem Sci. 2012 Oct;37(10):436-46
pubmed: 22921610
Oncogene. 2018 Feb 1;37(5):555-565
pubmed: 28991235
Cell. 2015 Mar 12;160(6):1125-34
pubmed: 25768908
Nucleic Acids Res. 2012 Aug;40(15):e115
pubmed: 22730293
Int J Mol Sci. 2018 Apr 27;19(5):
pubmed: 29702599
Mol Cell. 2014 Jun 5;54(5):716-27
pubmed: 24905005
PLoS One. 2013 Jun 26;8(6):e66609
pubmed: 23840508
J Surg Oncol. 2012 Jun 1;105(7):655-61
pubmed: 22213144
EMBO Rep. 2008 Jun;9(6):582-9
pubmed: 18483486
J Exp Med. 2018 Apr 2;215(4):1153-1168
pubmed: 29449309
Clin Chim Acta. 2015 Apr 15;444:132-6
pubmed: 25689795
Genes Dev. 2008 Apr 1;22(7):894-907
pubmed: 18381893
Apoptosis. 2004 Sep;9(5):573-82
pubmed: 15314285
J Phys Chem B. 2013 Oct 24;117(42):13164-74
pubmed: 23679052
BMC Cancer. 2014 Feb 12;14:85
pubmed: 24521357
Breast Cancer. 2018 Jan;25(1):1-7
pubmed: 28721656
Sci Rep. 2015 Oct 23;5:15464
pubmed: 26494317
PLoS One. 2015 Oct 20;10(10):e0141214
pubmed: 26485708
Oncotarget. 2017 Aug 10;8(59):99482-99494
pubmed: 29245917
Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2858-63
pubmed: 23386720
Cell. 2011 Aug 5;146(3):353-8
pubmed: 21802130
Nature. 2013 Mar 21;495(7441):333-8
pubmed: 23446348
Int J Cancer. 2013 Feb 15;132(4):745-54
pubmed: 22753312
Oncotarget. 2016 May 3;7(18):26680-91
pubmed: 27058418
EMBO Mol Med. 2016 Oct 4;8(10):1143-1161
pubmed: 27596438
Nucleic Acids Res. 2015 Jan;43(Database issue):D204-12
pubmed: 25348405
RNA. 2013 Feb;19(2):141-57
pubmed: 23249747
Semin Cancer Biol. 2018 Dec;53:42-47
pubmed: 30017637
Genomics. 2017 Oct;109(5-6):401-407
pubmed: 28655641
EMBO Rep. 2010 Sep;11(9):670-7
pubmed: 20706219
Cancer Lett. 2017 Mar 1;388:208-219
pubmed: 27986464
Nucleic Acids Res. 2016 Jan 4;44(D1):D209-15
pubmed: 26450965
Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):5902-5907
pubmed: 29784817
Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18144-9
pubmed: 24154725
BMC Bioinformatics. 2009 Dec 15;10:421
pubmed: 20003500
Clin Cancer Res. 2011 Dec 15;17(24):7654-63
pubmed: 22042972
Sci Signal. 2009 Oct 13;2(92):ra62
pubmed: 19825827
Medicine (Baltimore). 2016 May;95(22):e3811
pubmed: 27258521
Biophys J. 2013 Mar 5;104(5):1203-13
pubmed: 23473503