Lipid Metabolism at the Nexus of Diet and Tumor Microenvironment.
cancer
cancer metabolism
diet
environmental heterogeneity
lipids
nutrient stress
obesity
tumor microenvironment
Journal
Trends in cancer
ISSN: 2405-8025
Titre abrégé: Trends Cancer
Pays: United States
ID NLM: 101665956
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
02
07
2019
revised:
24
09
2019
accepted:
26
09
2019
entrez:
19
11
2019
pubmed:
19
11
2019
medline:
17
7
2020
Statut:
ppublish
Résumé
Obesity is a leading contributing factor to cancer development worldwide. Epidemiological evidence suggests that diet affects cancer risk and also substantially alters therapeutic outcome. Therefore, studying the impact of diet in the development and treatment of cancer should be a clinical priority. In this Review, we set out the evidence supporting the role of lipid metabolism in shaping the tumor microenvironment (TME) and cancer cell phenotype. We will discuss how dietary lipids can impact phenotype thereby affecting disease trajectory and treatment response. Finally, we will posit potential strategies on how this knowledge can be exploited to increase treatment efficacy and patient survival.
Identifiants
pubmed: 31735288
pii: S2405-8033(19)30190-6
doi: 10.1016/j.trecan.2019.09.007
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
693-703Subventions
Organisme : Cancer Research UK
ID : C16420/A18066
Pays : United Kingdom
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.