Adult Human Dermal Progenitor Cell Transplantation Modulates the Functional Outcome of Split-Thickness Skin Xenografts.
SKP
cell transplant
dermal progenitor
fibroblast
itch
regeneration
skin
skin graft
stem cell
wound healing
Journal
Stem cell reports
ISSN: 2213-6711
Titre abrégé: Stem Cell Reports
Pays: United States
ID NLM: 101611300
Informations de publication
Date de publication:
10 12 2019
10 12 2019
Historique:
received:
25
10
2018
revised:
15
10
2019
accepted:
16
10
2019
pubmed:
19
11
2019
medline:
1
7
2020
entrez:
19
11
2019
Statut:
ppublish
Résumé
Following full-thickness skin injuries, epithelialization of the wound is essential. The standard of care to achieve this wound "closure" in patients is autologous split-thickness skin grafting (STSG). However, patients living with STSGs report significant chronic impairments leading to functional deficiencies such as itch, altered sensation, fragility, hypertrophic scarring, and contractures. These features are attributable to the absence of functional dermis combined with the formation of disorganized fibrotic extracellular matrix. Recent work has demonstrated the existence of dermal progenitor cells (DPCs) residing within hair follicles that function to continuously regenerate mesenchymal tissue. The present work examines whether cultured DPCs could regenerate dermis within an STSG and improve overall graft function. Adult human DPCs were transplanted into a full-thickness skin wound in immune-compromised mice and closed with a human STSG. At 3 months, human DPCs (hDPCs) had successfully integrated into the xenograft and differentiated into various regionally specified phenotypes, improving both viscoelastic properties of the graft and mitigating pruritus.
Identifiants
pubmed: 31735655
pii: S2213-6711(19)30372-8
doi: 10.1016/j.stemcr.2019.10.011
pmc: PMC6915850
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1068-1082Subventions
Organisme : CIHR
Pays : Canada
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
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