Targeted delivery of functionalized PLGA nanoparticles to macrophages by complexation with the yeast Saccharomyces cerevisiae.
drug delivery
immunotherapy
nanomedicine
phagocytosis
yeast
Journal
Biotechnology and bioengineering
ISSN: 1097-0290
Titre abrégé: Biotechnol Bioeng
Pays: United States
ID NLM: 7502021
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
28
08
2019
revised:
06
11
2019
accepted:
10
11
2019
pubmed:
19
11
2019
medline:
23
2
2021
entrez:
19
11
2019
Statut:
ppublish
Résumé
Nanoparticles (NPs) are able to deliver a variety of substances into eukaryotic cells. However, their usage is often hampered by a lack of specificity, leading to the undesired uptake of NPs by virtually all cell types. In contrast to this, yeast is known to be specifically taken up into immune cells after entering the body. Therefore, we investigated the interaction of biodegradable surface-modified poly(lactic-co-glycolic acid) (PLGA) particles with yeast cells to overcome the unspecificity of the particulate carriers. Cells of different Saccharomyces cerevisiae strains were characterized regarding their interaction with PLGA-NPs under isotonic and hypotonic conditions. The particles were shown to efficiently interact with yeast cells leading to stable NP/yeast-complexes allowing to associate or even internalize compounds. Notably, applying those complexes to a coculture model of HeLa cells and macrophages, the macrophages were specifically targeted. This novel nano-in-micro carrier system suggests itself as a promising tool for the delivery of biologically active agents into phagocytic cells combining specificity and efficiency.
Substances chimiques
Polylactic Acid-Polyglycolic Acid Copolymer
1SIA8062RS
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
776-788Subventions
Organisme : Saarland Landesforschungsförderung
ID : LFFP 1303
Pays : International
Organisme : Saarland Landesforschungsförderung
ID : LFFP 17/08
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : KI702
Pays : International
Informations de copyright
© 2019 The Authors. Biotechnology and Bioengineering published by Wiley Periodicals, Inc.
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