Pharmacological and Behavioral Effects of the Synthetic Cannabinoid AKB48 in Rats.

AKB48 AM251 cardiorespiratory changes conditioned place preference (CPP) microdialysis prepulse inhibition (PPI) sensorimotor responses synthetic cannabinoids

Journal

Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481

Informations de publication

Date de publication:
2019
Historique:
received: 09 08 2019
accepted: 14 10 2019
entrez: 19 11 2019
pubmed: 19 11 2019
medline: 19 11 2019
Statut: epublish

Résumé

AKB48 is a designer drug belonging to the indazole synthetic cannabinoids class, illegally sold as herbal blend, incense, or research chemicals for their psychoactive cannabis-like effects. In the present study, we investigated the

Identifiants

pubmed: 31736697
doi: 10.3389/fnins.2019.01163
pmc: PMC6831561
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1163

Informations de copyright

Copyright © 2019 Bilel, Tirri, Arfè, Stopponi, Soverchia, Ciccocioppo, Frisoni, Strano-Rossi, Miliano, De-Giorgio, Serpelloni, Fantinati, De Luca, Neri and Marti.

Références

Br J Pharmacol. 2004 Jul;142(6):943-52
pubmed: 15226190
Forensic Sci Int. 2013 Apr 10;227(1-3):21-32
pubmed: 23063179
Behav Pharmacol. 2014 Jun;25(3):253-7
pubmed: 24625557
J Pharmacol Exp Ther. 1998 Jun;285(3):995-1004
pubmed: 9618400
J Emerg Med. 2016 Feb;50(2):258-62
pubmed: 26514310
Neuropharmacology. 2015 Aug;95:68-82
pubmed: 25769232
AAPS J. 2015 Sep;17(5):1237-45
pubmed: 26002511
AAPS J. 2013 Oct;15(4):1091-8
pubmed: 23913126
Neuron. 2007 Apr 19;54(2):291-301
pubmed: 17442249
Psychopharmacology (Berl). 2012 Feb;219(3):835-45
pubmed: 21773721
Clin Ther. 2018 Sep;40(9):1457-1466
pubmed: 30180974
Hum Psychopharmacol. 2015 Jul;30(4):302-18
pubmed: 26216567
Front Psychiatry. 2017 Aug 04;8:130
pubmed: 28824464
J Psychopharmacol. 2006 Jul;20(4):471-84
pubmed: 16174673
Life Sci. 2009 Jul 31;85(5-6):248-54
pubmed: 19508876
Neuropharmacology. 2016 Jun;105:630-638
pubmed: 26686391
Analyst. 2015 Aug 7;140(15):4932-48
pubmed: 26031385
Neuroscience. 1998 Mar;83(2):393-411
pubmed: 9460749
Clin Toxicol (Phila). 2014 Apr;52(4):239-41
pubmed: 24654801
Psychopharmacology (Berl). 2000 Jan;147(4):436-8
pubmed: 10672638
Neuron. 2014 Sep 3;83(5):1200-12
pubmed: 25155959
Neuroscience. 2015 Aug 6;300:174-88
pubmed: 25987201
Brain Sci. 2018 Jun 29;8(7):null
pubmed: 29966280
Front Neurosci. 2016 Apr 19;10:153
pubmed: 27147945
Nature. 2000 Nov 2;408(6808):96-101
pubmed: 11081515
ACS Chem Neurosci. 2015 Sep 16;6(9):1546-59
pubmed: 26134475
Psychopharmacology (Berl). 2005 Jan;177(3):264-71
pubmed: 15290008
Behav Pharmacol. 2002 Feb;13(1):29-37
pubmed: 11990717
Hum Psychopharmacol. 2017 May;32(3):
pubmed: 28597570
J Anal Toxicol. 2015 Jul-Aug;39(6):426-35
pubmed: 25957385
Prog Neuropsychopharmacol Biol Psychiatry. 2012 Dec 3;39(2):234-43
pubmed: 22561602
Proc Natl Acad Sci U S A. 1988 Jul;85(14):5274-8
pubmed: 2899326
Hum Psychopharmacol. 2017 May;32(3):
pubmed: 28657178
Hum Psychopharmacol. 2017 May;32(3):
pubmed: 28657187
ACS Chem Neurosci. 2016 Sep 21;7(9):1241-54
pubmed: 27421060
Pediatrics. 2011 Dec;128(6):e1622-7
pubmed: 22065271
PLoS One. 2013;8(1):e53082
pubmed: 23308141
Am J Psychiatry. 1991 Oct;148(10):1301-8
pubmed: 1654746
Drug Test Anal. 2016 Oct;8(10):1030-1038
pubmed: 26768345
Psychopharmacology (Berl). 1996 Apr;124(4):315-22
pubmed: 8739546
Drug Alcohol Depend. 2011 Sep 1;117(2-3):152-7
pubmed: 21316162
Behav Brain Res. 2006 Jan 6;166(1):101-9
pubmed: 16143410
Br J Pharmacol. 2008 Jan;153(2):319-34
pubmed: 17994113
Case Rep Cardiol. 2014;2014:120607
pubmed: 24963415
Life Sci. 2014 Feb 27;97(1):55-63
pubmed: 24071522
Hum Psychopharmacol. 2017 May;32(3):
pubmed: 28657188
Biochem Pharmacol. 2012 Apr 1;83(7):952-61
pubmed: 22266354
Pharmacol Biochem Behav. 2006 Jun;84(2):330-6
pubmed: 16820196
J Spec Pediatr Nurs. 2014 Apr;19(2):119-26
pubmed: 24320158
Psychopharmacology (Berl). 1998 Feb;135(4):324-32
pubmed: 9539255
Biomol Ther (Seoul). 2015 Nov;23(6):590-6
pubmed: 26535085
Behav Pharmacol. 2015 Aug;26(5):460-8
pubmed: 26061356
BMC Pharmacol Toxicol. 2016 Jan 16;17:2
pubmed: 26772803
Forensic Sci Int. 2016 Aug;265:116-20
pubmed: 26874736
ACS Chem Neurosci. 2015 Aug 19;6(8):1445-58
pubmed: 25921407
Psychopharmacology (Berl). 2003 Jan;165(2):128-35
pubmed: 12404071
Neuropharmacology. 2015 Dec;99:705-14
pubmed: 26327678
Addiction. 2010 Oct;105(10):1859-60
pubmed: 20840203
Drug Alcohol Depend. 2017 Oct 1;179:387-394
pubmed: 28846955
Front Neurosci. 2014 Jul 25;8:216
pubmed: 25120419
Respir Med Case Rep. 2017 Jul 29;22:137-141
pubmed: 28794966
Front Pharmacol. 2016 Sep 09;7:303
pubmed: 27667973
Int J Legal Med. 2019 May;133(3):811-820
pubmed: 30056621
West J Emerg Med. 2018 May;19(3):567-572
pubmed: 29760857
Front Psychiatry. 2018 Feb 27;9:55
pubmed: 29535650
Naunyn Schmiedebergs Arch Pharmacol. 2003 Oct;368(4):301-8
pubmed: 13680088
Forensic Sci Int. 2015 Jan;246:98-103
pubmed: 25485949
Eur J Neurosci. 1999 Dec;11(12):4213-25
pubmed: 10594647
Science. 1997 Jun 27;276(5321):2048-50
pubmed: 9197269
Psychopharmacology (Berl). 2006 Sep;188(1):63-74
pubmed: 16850116
Psychopharmacology (Berl). 2008 Jun;198(3):375-85
pubmed: 18446326
J Pharmacol Exp Ther. 2018 Dec;367(3):543-550
pubmed: 30266766
Prog Neuropsychopharmacol Biol Psychiatry. 2016 Jun 3;67:31-50
pubmed: 26780169
Psychopharmacology (Berl). 2016 Oct;233(21-22):3685-3709
pubmed: 27527584
Interdiscip Toxicol. 2013 Sep;6(3):126-35
pubmed: 24678249
Neuropharmacology. 2018 Oct;141:167-180
pubmed: 30165078
Addict Biol. 2007 Sep;12(3-4):227-462
pubmed: 17678505
J Clin Pharmacol. 2017 Mar;57(3):297-304
pubmed: 27610597
Psychopharmacology (Berl). 2000 Jul;151(1):25-30
pubmed: 10958113
Neuropharmacology. 2011 Dec;61(7):1070-87
pubmed: 21669214

Auteurs

Sabrine Bilel (S)

Department of Morphology, Experimental Medicine and Surgery, Section of Legal Medicine and Laboratory for Technologies of Advanced Therapies (LTTA) Centre, University of Ferrara, Ferrara, Italy.

Micaela Tirri (M)

Department of Morphology, Experimental Medicine and Surgery, Section of Legal Medicine and Laboratory for Technologies of Advanced Therapies (LTTA) Centre, University of Ferrara, Ferrara, Italy.

Raffaella Arfè (R)

Department of Morphology, Experimental Medicine and Surgery, Section of Legal Medicine and Laboratory for Technologies of Advanced Therapies (LTTA) Centre, University of Ferrara, Ferrara, Italy.
Section of Legal Medicine, Institute of Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.

Serena Stopponi (S)

Pharmacology Unit, School of Pharmacy, University of Camerino, Camerino, Italy.

Laura Soverchia (L)

Pharmacology Unit, School of Pharmacy, University of Camerino, Camerino, Italy.

Roberto Ciccocioppo (R)

Pharmacology Unit, School of Pharmacy, University of Camerino, Camerino, Italy.

Paolo Frisoni (P)

Department of Morphology, Experimental Medicine and Surgery, Section of Legal Medicine and Laboratory for Technologies of Advanced Therapies (LTTA) Centre, University of Ferrara, Ferrara, Italy.

Sabina Strano-Rossi (S)

Section of Legal Medicine, Institute of Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.

Cristina Miliano (C)

Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.

Fabio De-Giorgio (F)

Section of Legal Medicine, Institute of Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.

Giovanni Serpelloni (G)

Department of Psychiatry in the College of Medicine, Drug Policy Institute, University of Florida, Gainesville, FL, United States.

Anna Fantinati (A)

Department of Chemistry and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy.

Maria Antonietta De Luca (MA)

Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.

Margherita Neri (M)

Department of Morphology, Experimental Medicine and Surgery, Section of Legal Medicine and Laboratory for Technologies of Advanced Therapies (LTTA) Centre, University of Ferrara, Ferrara, Italy.

Matteo Marti (M)

Department of Morphology, Experimental Medicine and Surgery, Section of Legal Medicine and Laboratory for Technologies of Advanced Therapies (LTTA) Centre, University of Ferrara, Ferrara, Italy.
Department of Anti-Drug Policies, Presidency of the Council of Ministers, Collaborative Center for the Italian National Early Warning System, Ferrara, Italy.

Classifications MeSH