MiR-29 Regulates

Sirtuin 1 (Sirt1) lipogenesis liver miR-29 microRNA (miRNA)

Journal

Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006

Informations de publication

Date de publication:
2019
Historique:
received: 08 08 2019
accepted: 15 10 2019
entrez: 19 11 2019
pubmed: 19 11 2019
medline: 19 11 2019
Statut: epublish

Résumé

MicroRNAs (miRNAs) are known regulators of lipid homeostasis. We recently demonstrated that miR-29 controls the levels of circulating cholesterol and triglycerides, but the mechanisms remained unknown. In the present study, we demonstrated that systemic delivery of locked nucleic acid inhibitor of miR-29 (LNA29) through subcutaneous injection effectively suppresses hepatic expression of miR-29 and dampens

Identifiants

pubmed: 31736786
doi: 10.3389/fphys.2019.01367
pmc: PMC6828850
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1367

Subventions

Organisme : NIDDK NIH HHS
ID : P01 DK094779
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128996
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK105965
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK056350
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL116263
Pays : United States

Informations de copyright

Copyright © 2019 Hung, Kanke, Kurtz, Cubitt, Bunaciu, Zhou, White, Vickers, Hussain, Li and Sethupathy.

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Auteurs

Yu-Han Hung (YH)

Department of Biomedical Sciences, Cornell University, Ithaca, NY, United States.

Matt Kanke (M)

Department of Biomedical Sciences, Cornell University, Ithaca, NY, United States.

Catherine Lisa Kurtz (CL)

Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

Rebecca L Cubitt (RL)

Department of Biomedical Sciences, Cornell University, Ithaca, NY, United States.

Rodica P Bunaciu (RP)

Department of Biomedical Sciences, Cornell University, Ithaca, NY, United States.

Liye Zhou (L)

Diabetes and Obesity Research Center, NYU Winthrop Hospital, Mineola, NY, United States.

Phillip J White (PJ)

Duke Molecular Physiology Institute, Duke University, Durham, NC, United States.

Kasey C Vickers (KC)

Department of Medicine, Vanderbilt University, Nashville, TN, United States.

Mohammed Mahmood Hussain (MM)

Diabetes and Obesity Research Center, NYU Winthrop Hospital, Mineola, NY, United States.

Xiaoling Li (X)

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Durham, NC, United States.

Praveen Sethupathy (P)

Department of Biomedical Sciences, Cornell University, Ithaca, NY, United States.

Classifications MeSH