Production and Immunogenicity of Soluble Plant-Produced HIV-1 Subtype C Envelope gp140 Immunogens.

HIV glycoprotein immunogenicity modified vaccinia Ankara plants

Journal

Frontiers in plant science
ISSN: 1664-462X
Titre abrégé: Front Plant Sci
Pays: Switzerland
ID NLM: 101568200

Informations de publication

Date de publication:
2019
Historique:
received: 29 05 2019
accepted: 07 10 2019
entrez: 19 11 2019
pubmed: 19 11 2019
medline: 19 11 2019
Statut: epublish

Résumé

The development of effective vaccines is urgently needed to curb the spread of human immunodeficiency virus type 1 (HIV-1). A major focal point of current HIV vaccine research is the production of soluble envelope (Env) glycoproteins which reproduce the structure of the native gp160 trimer. These antigens are produced in mammalian cells, which requires a sophisticated infrastructure for manufacture that is mostly absent in developing countries. The production of recombinant proteins in plants is an attractive alternative for the potentially cheap and scalable production of vaccine antigens, especially for developing countries. In this study, we developed a transient expression system in

Identifiants

DOI: 10.3389/fpls.2019.01378 PMID: 31737007 PMC: PMC6831737
pubmed: 31737007
doi: 10.3389/fpls.2019.01378
pmc: PMC6831737
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1378

Informations de copyright

Copyright © 2019 Margolin, Chapman, Meyers, van Diepen, Ximba, Hermanus, Crowther, Weber, Morris, Williamson and Rybicki.

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Auteurs

Emmanuel Margolin (E)

Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Biopharming Research Unit, Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa.

Rosamund Chapman (R)

Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Ann E Meyers (AE)

Biopharming Research Unit, Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa.

Michiel T van Diepen (MT)

Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Phindile Ximba (P)

Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Biopharming Research Unit, Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa.

Tandile Hermanus (T)

National Institute for Communicable Diseases of the National Health Laboratory Service, Sandringham, South Africa.
Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.

Carol Crowther (C)

National Institute for Communicable Diseases of the National Health Laboratory Service, Sandringham, South Africa.
Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.

Brandon Weber (B)

Structural Biology Research Unit, Division of Medical Biochemistry, Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town, South Africa.

Lynn Morris (L)

National Institute for Communicable Diseases of the National Health Laboratory Service, Sandringham, South Africa.
Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.

Anna-Lise Williamson (AL)

Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Edward P Rybicki (EP)

Biopharming Research Unit, Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa.
Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Classifications MeSH